Disease modifying activity of celecoxib on articular cartilage in osteoarthritis.
Recruiting
- Conditions
- end stage knee osteoarthritis
- Registration Number
- NL-OMON25692
- Lead Sponsor
- Sint Franciscus Gasthuis hospital Rotterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 172
Inclusion Criteria
Patients with knee osteoarthritis eligible for and on the waiting list for total knee replacement surgery at the Sint Fransiscus Gasthuis hospital in Rotterdam.
Exclusion Criteria
1. Patients who are eligible for a total knee replacement operation for other reasons than OA;
2. Patients with an increased risk for gastro-intestinal bleeding;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in proteoglycan release of the OA cartilage under the influence of celecoxib.
- Secondary Outcome Measures
Name Time Method Changes in several biochemical and histochemical characteristics of the OA cartilage including proteoglycan synthesis rate, proteoglycan content, prostaglandin E2 production, and COX-1 and COX-2 expression of cartilage.