Improved Prediction of Clinical Outcome With the Use of Global Strain and Mechanical Dispersion in Patients With Myocardial Infarction and Heart Failure
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 3,100
- Locations
- 8
- Primary Endpoint
- Ventricular arrhythmia and death after acute myocardial infarction or heart failure.
Study Overview
Brief Summary
The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless of cause.
Detailed Description
- The main aim of this study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than left ventricular ejection fraction in patients with myocardial infarction and heart failure.
- In patients who receive internal cardioverter defibrillator(ICD) the main aim is to investigate if mechanical dispersion may predict ventricular arrhythmias better than EF.
-
No interventions,only evaluation of the measurements obtained with transthoracic echocardiography.
-
Follow up for 3 years, extended from 3 to 5 years.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All patients with
- •myocardial infarction
- •heart failure( defined as heart failure symptoms: reduced left ventricular function/ and or heart failure signs on chest x ray.
- •planned for primary prophylactic ICD
- •over 18 years of age
- •Informed consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Ventricular arrhythmia and death after acute myocardial infarction or heart failure.
Time Frame: 5 years or more
Arrhythmic events during follow-up are defined as documented sustained ventricular tachycardia, ventricular fibrillation, and SCD. Survival is assessed by medical charts if patients are within the uptake area of the hospital and by the Norwegian death registry Folkeregisteret.
Secondary Outcomes
No secondary outcomes reported
Investigators
Thor Edvardsen
Professor, Chief department of Cardiology Oslo university hospital
Oslo University Hospital