Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Not Applicable

Completed

• Conditions: Adolescent Idiopathic Scoliosis
• Interventions: Device: MRI

• Registration Number: NCT02302534
• Lead Sponsor: University Hospital, Tours

Brief Summary

Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms.

Without fully convincing model of the emergence and development of AIS, their multifactorial nature seems evident. Several pathophysiological theories involving the central nervous system have been proposed: the AIS would be associated with disturbances of proprioceptive or sensory perception, and/or with integration of this information. This would result in an abnormal body image, responsible for sensorimotor asymmetry that may promote or cause the deformation.

The Main aim of this study is to find cortical and subcortical morphometric differences in the most common population of AIS (right thoracic AIS) compared to healthy adolescent control girls.

Secondary Objectives are to study the cerebral white matter of the same groups (fractional anisotropy in the main white matter tracts), and activation of sensorimotor neural networks (fMRI activation and functional brain connectivity).

Abnormalities of the studied parameters may be used as biomarkers for AIS diagnosis and classification.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2014-10-21
• Study First Submitted QC: 2014-11-26
• Study First Posted: 2014-11-27
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-31
• Last Update Posted: 2015-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 16

Inclusion Criteria

• female
• between 14 and 16 years old
• normal neurological examination
• right handed
• informed consent
• informed consent form signed by a parent or a holder of parental authority
• affiliated to medical insurance
• negative urine pregnancy test For patients (A-STD) : right thoracic scoliosis with a Cobb angle between 20 and 40° For healthy volunteers (A-N) : no clinical scoliosis

Exclusion Criteria

• pregnant or lactating woman
• antecedents of cranial trauma or cranial intervention, of migraine, of spinal trauma, of scoliosis intervention
• no idiopathic scoliosis
• contraindications to MRI
• patient with a legal protection measure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patients	MRI	2 groups with MRI : - 8 right thoracic AIS participants (Cobb angle between 20 and 40°)
controls subjects	MRI	- 8 healthy controls (no clinical scoliosis)

Primary Outcome Measures

Name	Time	Method
Variation in regional cortical and subcortical volume, as measured by MRI	One day

Secondary Outcome Measures

Name	Time	Method
Variation in fractional anisotropy in the main white matter tracts, as measured by MRI	one day
Variation in activation of sensorimotor neural networks, as measured by MRI	one day

Trial Locations

Locations (1)

University Hospital of Tours; 🇫🇷 Tours, France