Efficacy of positive end-expiratory pressure titration after the alveolar recruitment manoeuvre in patients with acute respiratory distress syndrome

Completed

• Conditions: Acute respiratory distress syndrome (ARDS); Respiratory; Adult respiratory distress syndrome

• Registration Number: ISRCTN79027921
• Lead Sponsor: Asan Medical Center (South Korea)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10-31
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Criteria of ARDS proposed by the American-European Consensus Conference:
1.1. Acute onset
1.2. Presence of hypoxaemia (arterial oxygen tension/fraction of inspired oxygen (FiO2) (PF ratio) less than 200 mmHg regardless of the PEEP level)
1.3. Bilateral and diffuse opacities seen on frontal chest X-ray film
1.4. Absence of left ventricular failure with pulmonary arterial occluded pressure less than 18 mmHg
2. Recruited into the trial within 48 hours of meeting above ARDS criteria
3. Aged 18 - 82 years, either sex

Exclusion Criteria

1. Haemodynamic instability
2. Elevated intracranial pressure
3. High risk of mortality within 3 months from other than ARDS (severe organ failure, and cancer patients in terminal stages of the disease)
4. Refusal to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified