Postprandial insulin release and the impact on muscle perfusio

Completed

• Conditions: Spiermetabolisme; Diabetes (mellitus type 2); Non-insulin dependent diabetes mellitus.; 10018424; 10047066

• Registration Number: NL-OMON34290
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

20 Healthy male volunteers, aged between 20 and 30
20 Healthy male volunteers, aged between 65 and 80
20 Male volunteers with type 2 Diabetes Mellitus, aged between 65 and 80

Exclusion Criteria

cardio vascular history
Use of insuline medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Microvascular perfusion expressed in glycocalyx permeability (µm), measured<br /><br>with orthogonal polarisation spectrometry in the oral cavity and<br /><br>capillarization (expressed in numbers of capillaries per fiber type) of muscle<br /><br>tissue obtained from a muscle biopsy.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>glucose concentration<br /><br>Postprandial plasma insulin concentration<br /><br>Hyperglycemia (glucose concentration >10mmol/L)<br /><br>Insulin resistance (expressed as OGIS).<br /><br>Total and fiber specific muscle mass</p><br>