The Effect of Electrical Stimulation on the Expression of VEGF, VEGFR-2, HIF and NO in the Diabetic Foot Ulcer
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Diabetic Foot
- Sponsor
- Tarbiat Modarres University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The wound fluid level of VEGF, VEGFR-2, HIF-1α and NO (pg/ml)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to determine whether electrical stimulation is effective in the expression of VEGF, VEGFR-2, HIF-1α and NO and healing in diabetic foot ulcer.
Detailed Description
30 type 2 diabetic patients with ischemic foot ulceration were enrolled. Patients were randomly assigned to electrical stimulation (ES, n=15) or sham ES (placebo, n=15) groups. ES group received cathodal direct current for 1 h/day, 3 days/week, for 4 weeks (12 sessions). Wound fluid sample was collected for VEGF, VEGFR-2, HIF-1α and NO measurement in the first and last treatment sessions before and after intervention. Wound surface area (WSA) was measured at 1st, 6th, and 12th session.
Investigators
giti torkaman
Professor of physical therapy, Physical therapy department, Faculty of medical sciences, Tarbiat modares univercity
Tarbiat Modarres University
Eligibility Criteria
Inclusion Criteria
- •Ischemic diabetic foot ulcer
- •Wagner classification DFU 2
- •0.5\<ABI\<0.9
- •Mild to moderate diabetic neuropathy
Exclusion Criteria
- •Fracture in a lower limb
- •A severe infection
- •A malignancy
- •Kidney failure
- •Skin diseases
- •Osteomyelitis
- •Pregnancy
Outcomes
Primary Outcomes
The wound fluid level of VEGF, VEGFR-2, HIF-1α and NO (pg/ml)
Time Frame: Change from Baseline in wound fluid level of VEGF, VEGFR-2, HIF-1α and NO at 4 weeks
Secondary Outcomes
- Wound surface area(cm2)(Change from Baseline in wound surface area at 2 and 4 weeks)