BONG: Reducing severe Breathlessness with Dronabinol in the severe and very severe chronic obstructive pulmonary disease patient group
- Conditions
- Chronic obstructive pulmonary diseaseTherapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]
- Registration Number
- CTIS2024-513593-22-00
- Lead Sponsor
- illebaelt Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 30
Refractory dyspnea despite optimal treatment, COPD (GOLD 3,4), Breathlessness corresponding to mMRC score = 3, Informed written consent, Age = 18 years, Cognitive relevant, of legal age, Understands and speaks Danish, For fertile women defined by amenorrhea for less than 12 months: negative HCG before entry into the trial, For fertile and sexually active subjects: use of safe contraception during medication intake and 4 weeks after: intrauterine device (IUD) or hormonal contraception (oral contraceptive pill, implant, transdermal patch, vaginal ring or depot injection).
Ongoing infection or exacerbation of COPD within the last month (30 days), Regular treatment with THC or CBD within 1 month (30 days), Life expectancy less than 3 months (90 days), Treatment with medicines that, according to the summary of product characteristics, are strong inhibitors or inducers of CYP3A4, CYP2C9 or CYP2C19, History of or current evidence of significant medical or psychiatric disorder that is considered by the investigator to put the subject at greater risk of experiencing an adverse event, Current or past substance abuse where the investigator finds it too risky for the subject to be included in the study
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method