Antipyretics for Preventing Recurrences of Febrile Seizures
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 231
- 试验地点
- 1
- 主要终点
- recurrence of febrile seizure
研究概览
简要总结
We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic medication every time when the child had a new episode of fever during two years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 3 Months 至 4 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •First febrile convulsion
排除标准
- •Any prior convulsion or antiepileptic medication
研究组 & 干预措施
1 drug
diclofenac 15 mg/kg suppository once
干预措施: Diclofenac, Paracetamol, Ibuprofen (Drug)
2 drug
Placebo suppository once
干预措施: Diclofenac, Paracetamol, Ibuprofen (Drug)
3 drug
acetaminophen mixture 15 mg/kg up to four times a day
干预措施: Diclofenac, Paracetamol, Ibuprofen (Drug)
4 drug
ibuprofen mixture 10 mg/kg up to four times a day
干预措施: Diclofenac, Paracetamol, Ibuprofen (Drug)
5 drug
oral placebo mixture up to four times a day
干预措施: Diclofenac, Paracetamol, Ibuprofen (Drug)
结局指标
主要结局
recurrence of febrile seizure
时间窗: two years
次要结局
- we only had the primary outcome measure(two years)