Antipyretics for Preventing Recurrences of Febrile Seizures
Overview
- Phase
- Phase 4
- Intervention
- Diclofenac, Paracetamol, Ibuprofen
- Conditions
- Recurrence of Febrile Seizure
- Sponsor
- University of Oulu
- Enrollment
- 231
- Locations
- 1
- Primary Endpoint
- recurrence of febrile seizure
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic medication every time when the child had a new episode of fever during two years.
Investigators
Eligibility Criteria
Inclusion Criteria
- •First febrile convulsion
Exclusion Criteria
- •Any prior convulsion or antiepileptic medication
Arms & Interventions
1 drug
diclofenac 15 mg/kg suppository once
Intervention: Diclofenac, Paracetamol, Ibuprofen
2 drug
Placebo suppository once
Intervention: Diclofenac, Paracetamol, Ibuprofen
3 drug
acetaminophen mixture 15 mg/kg up to four times a day
Intervention: Diclofenac, Paracetamol, Ibuprofen
4 drug
ibuprofen mixture 10 mg/kg up to four times a day
Intervention: Diclofenac, Paracetamol, Ibuprofen
5 drug
oral placebo mixture up to four times a day
Intervention: Diclofenac, Paracetamol, Ibuprofen
Outcomes
Primary Outcomes
recurrence of febrile seizure
Time Frame: two years
Secondary Outcomes
- we only had the primary outcome measure(two years)