Efficacy of monthly minodronate for the treatment of osteoporosis associated with rheumatoid arthritis after previous treatment with bisphosphonates
Not Applicable
- Conditions
- Osteoporosis
- Registration Number
- JPRN-UMIN000011087
- Lead Sponsor
- Osaka University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients who underwent rheumatoid arthritis surgery less than three months before entry 2. Patients experienced any fracture less than three months before surgery 3. Patients with active RA and inadequate response to treatment 4. Patients with peptic ulcers 5. Patients with esophageal stricture or achalasia 6. Patients unable to remain upright for 30 min after dosing 7. Patients with hypocalcaemia 8. Females with pregnancy and lactating
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (1) Changes in bone mineral density (2) Changes TRACP-5b, CTX, P1NP, BAP, uDPD, ucOC, MMP-3, CRP, 1,25(OH)2VtD, serumCa, and serumP
- Secondary Outcome Measures
Name Time Method (1) MHAQ (2) mini-JOQOL (3) Patient Satisfaction Questionnaire (4) Treatment adherence (5) Side effects (6) Incident fracture