Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 141
- 试验地点
- 1
- 主要终点
- total duration of postoperative ventilator care
研究概览
简要总结
Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively. Some of the recipients experience difficulty in weaning off from the mechanical ventilator due to various causes. This study is to investigate the relationship between the inflammatory gene polymorphism, known for acute lung injury, and the duration of mechanical ventilatory care for such liver transplantation recipients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20-65 years old
- •scheduled for liver transplantation
排除标准
- •Patients under mechanical ventilation prior to surgery
- •patients with muscular skeletal disorder, probable cause for respiratory depression
- •patients not able to read, or understand the consent form
- •ethnicity, other than asian
- •patients refusal
结局指标
主要结局
total duration of postoperative ventilator care
时间窗: an expected average of 2-3 days
Time for successful weaning from ventilator could correlate with the inflammtory gene polymorphism, especially those related to acute lung injury.
次要结局
未报告次要终点