Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation

Completed

• Conditions: Patients With Postoperative Mechanical Ventilation After Liver Transplantation
• Interventions: Other: Mechanical ventilatory lung care

• Registration Number: NCT02402634
• Lead Sponsor: Yonsei University

Brief Summary

Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively. Some of the recipients experience difficulty in weaning off from the mechanical ventilator due to various causes. This study is to investigate the relationship between the inflammatory gene polymorphism, known for acute lung injury, and the duration of mechanical ventilatory care for such liver transplantation recipients.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Study First Submitted: 2015-03-25
• Study First Submitted QC: 2015-03-25
• Study First Posted: 2015-03-30
• Primary Completion: 2018-01-08
• Study Completion: 2018-01-08
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-14
• Last Update Posted: 2019-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 141

Inclusion Criteria

1. 20-65 years old
2. scheduled for liver transplantation

Read More

Exclusion Criteria

1. Patients under mechanical ventilation prior to surgery
2. patients with muscular skeletal disorder, probable cause for respiratory depression
3. patients not able to read, or understand the consent form
4. ethnicity, other than asian
5. patients refusal

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mechanical ventilatory lung care	Mechanical ventilatory lung care	liver transplantation recipients under mechanical ventilatory lung care

Primary Outcome Measures

Name	Time	Method
total duration of postoperative ventilator care	an expected average of 2-3 days	Time for successful weaning from ventilator could correlate with the inflammtory gene polymorphism, especially those related to acute lung injury.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of