Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

• Conditions: Gastric Cancer
• Interventions: Diagnostic Test: different diseases

• Registration Number: NCT04624282
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.

Detailed Description

This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.

Study Timeline

• Study First Submitted: 2020-10-19
• Study Start: 2020-11-01
• Study First Submitted QC: 2020-11-05
• Study First Posted: 2020-11-10
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-17
• Last Update Posted: 2021-01-20
• Primary Completion: 2021-04-30
• Study Completion: 2021-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with chronic superficial gastritis and chronic atrophic gastritis
• Patients with gastric carcinoma

Exclusion Criteria

• Patients with history of surgery
• Patients with severe heart disease,lung disease or kidney disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with chronic superficial gastritis	different diseases	Patients with chronic superficial gastritis
Patients with gastric carcinoma	different diseases	Patients with gastric carcinoma
Patients with chronic atrophic gastritis	different diseases	Patients with chronic atrophic gastritis

Primary Outcome Measures

Name	Time	Method
Metabonomic difference in patients with chronic gastritis and gastric carcinoma	six months	1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis.

Secondary Outcome Measures

Name	Time	Method
Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma	six months	The researchers want to reveal the relationship between different metabolic sustances and disease result in patientswith chronic gastritis and gastric carcinoma.

Trial Locations

Locations (1)

2nd Affiliated Hospital, School of Medicine; 🇨🇳 Hangzhou, Zhejiang University, China