Feasibility study to use new techniques/biomarkers to measure oxidative stress and the influence of vitamin E and C on these parameters in patients suffering from intermittent claudicatio

Not Applicable

Completed

• Conditions: Intermittent claudication; Circulatory System; Peripheral vascular disease

• Registration Number: ISRCTN69086952
• Lead Sponsor: Máxima Medical Centre (The Netherlands)

Brief Summary

2008 results in https://doi.org/10.1002/nbm.1242 (added 26/03/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2004-04-01
• Study Start: 2007-02-23
• Last Update Posted: 12 April 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 17

Inclusion Criteria

Stable (more than six months regarding subjective walking distance) patients with intermittent claudication.

Exclusion Criteria

1. Patients with pre-existing renal dysfunction
2. Those not able to perform a standard walking test

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evels of 'new' parameters of oxidative stress like isofuranes and halogenated phospholipids are determined. Also vascular parameters (fibrinogen, Plasminogen Activator Inhibitor-1 [PAI-1] activity etc.,) and endothelial damage parameters (soluble thrombomodulin, von Willebrand factor etc.,) are determined. New techniques like multivariate NMR will be determined for their usefulness in the above mentioned type of studies.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures