Evaluation of effect of magnesium sulfate on reduction of cerebral vasospasm?
- Conditions
- Cerebral aneurism ?.Subarachnoid haemorrhage from intracranial artery, unspecified
- Registration Number
- IRCT2013042813159N1
- Lead Sponsor
- Vice Chancellor for Research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 46
The major inclusion criteria?:?
candidate for brain aneurysm surgery after 3 days of aneurysm bleeding;?
American Society of Anesthesiologists (ASA) class I and II.?
The major exclusion criteria:?
pathology of cardiovascular system; heart failure [Ejection fraction (EF) less than ??40%].
Previous history of hypertension; Liver or kidney diseases (impaired Liver function ?test (FT) and Glomerular filtration rate (GFR) less than 50 ml/min); Motor, ?neurological, and muscle disorders, coagulopathy [Prothrombin time (PT) more than ??16, International Normalized Ratio (INR) more than 1.5; Partial thromboplastin ?time (PTT) more than 35]; Hypomagnesaemia, More than 60 years of age;? History of allergy to any of the used medications in the experiment,?
? Overweight [Body mass index (BMI) more than 30]; Previous use of calcium channel ?blockers; Atrioventricular block.?
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vasospasm. Timepoint: After intervention, daily. Method of measurement: Angiography and transcranial Doppler.;Mean arterial pressure. Timepoint: Before infusion, 5 minutes after infusion, every 15 minutes after infusion. Method of measurement: Arterial Line during the surgery.;Heart rate. Timepoint: Before infusion, 5 minutes after infusion, every 15 minutes after infusion. Method of measurement: Heart monitoring during the surgery.
- Secondary Outcome Measures
Name Time Method Bleeding rate. Timepoint: End of surgery. Method of measurement: Based on CC of gases and suction contents.;The amount of anesthetic drugs used (propofol 2 mg/kg, fentanyl 2 mcg/kg, atracurium 0.5 mg/kg lidocaine 1.5 mg/kg). Timepoint: End of surgery. Method of measurement: Based on patient weight (kg) and Duration of Surgery.