Portal Hypertension Using Magnetic Resonance Elastography

Completed

• Conditions: Magnetic Resonance Imaging; Portal Hypertension

• Registration Number: NCT05749198
• Lead Sponsor: Yonsei University

Brief Summary

This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-02
• Primary Completion: 2019-09-30
• Study Completion: 2023-01-28
• Status Verified: 2023-02
• Study First Submitted: 2023-02-14
• Study First Submitted QC: 2023-02-28
• Last Update Submitted: 2023-02-28
• Study First Posted: 2023-03-01
• Last Update Posted: 2023-03-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• diagnosed liver cirrhosis
• requiring prophylactic treatment of esophageal varices

Exclusion Criteria

• the coexistence of hepatocellular carcinoma
• refractory ascites who regularly underwent large-volume paracentesis
• the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
• undergoing liver transplantation
• contraindication with magnetic resonance imaging

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change of portal pressure (HVPG) prior to and after treatment with NSBB	Change from baseline and at 6 months
Change of liver stiffness and spleen stiffness by MRE	Change from baseline stiffness of MRE at 6 months

Trial Locations

Locations (1)

Wonju Severance Christian Hospital; 🇰🇷 Wŏnju, Gangwon, Korea, Republic of