An Open-Label, Randomized, Parallel Group Study of Patients Treated with Paclitaxel with Standard Dosing versus Pharmacokinetic Guided Dose Adjustment in Patients with Advanced NSCLC

• Conditions: Stage III-IV Non Small Cell Lung Cancer (NSCLC); MedDRA version: 14.1Level: LLTClassification code 10025055Term: Lung cancer non-small cell stage IVSystem Organ Class: 100000004864; MedDRA version: 14.1Level: LLTClassification code 10025054Term: Lung cancer non-small cell stage IIIBSystem Organ Class: 100000004864; Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2010-023688-16-DE
• Lead Sponsor: CESAR Central European Society for Anticancer Drug Research-EWIV

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-12
• Last Update Posted: 16 February 2015

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 366

Inclusion Criteria

(1)Capable of understanding the protocol requirements and risks, and providing written informed consent.
(2)Patients with histologically confirmed NSCLC (stage IIIB-IV).
(3)Patients considered for first-line palliative chemotherapy with paclitaxel in combination with either cisplatin or carboplatin. Patients having received prior adjuvant non taxane-containing adjuvant chemotherapy are eligible.
(4)At least one bidimensionally measurable lesion according to RECIST 1.1.
(5)ECOG Performance Status (ECOG-PS) status = 2.
(6)Female or male patients of 18 to 75 years of age at randomization
(7)Women of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile) must use acceptable contraceptive methods (intrauterine device [IUD], oral contraceptive or double barrier device), and must have a negative serum pregnancy test within 1 week prior to beginning treatment on this trial. Nursing patients are excluded. Sexually active men must also use acceptable contraceptive methods (condom).
(8)An absolute neutrophil count >1,500 cells/ mm3 (= 1.5 G/l).
(9)Platelet count > 100,000/mm3.
(10)Total bilirubin = 2 x upper limit of normal.
(11)AST and ALT = 2.5 x upper limit of normal, or = 5 x upper limit of normal in case of liver metastases.
(12)Creatinine clearance (according to the Cockroft-Gault formula) =30ml/min. For patients planned to receive Cisplatin: Creatinine clearance =60ml/min.
(13)Patients suffering from asymptomatic brain metastases can be enrolled in case corticosteroid therapy is not indicated. Prior irradiation must be completed at least 4 weeks prior to first cycle of treatment.

Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 320
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 46

Exclusion Criteria

(1)Serious concomitant systemic disorders (e.g., active infection, severe heart disease, uncontrolled hypertension or diabetes mellitus) that, in the opinion of the investigator, would compromise the safety of the patient or compromise the patient’s ability to complete the study.
(2)A history of hypersensitivity reactions to drugs formulated in polyoxyethylated castor oil.
(3)Having received prior treatment with paclitaxel or cisplatin or carboplatin (other drugs/drug combinations are allowed).
(4)Concomitant treatment with any targeted drug (licensed or experimental) like bevacizumab or cetuximab.
(5)Any condition / concomitant disease not allowing chemotherapy with paclitaxel, the platinum compound (carboplatin or cisplatin) or required premedication for the treatment regimen.
(6)Pregnant/nursing women.
(7)Individuals known to be seropositive for human immunodeficiency virus, hepatitis C virus, hepatitis B surface antigen or syphilis.
(8)Treatment with cytotoxic or biologic agents or any experimental drug within the 4 weeks prior to beginning treatment on this study.
(9)Secondary malignancy within the last five years, with the exception of adequately treated carcinoma-in-situ of the uterine cervix, basal-cell carcinoma of the skin and pTa or pTis urothelial cancer.
(10)Medical or psychological conditions that would not permit the patient to complete the study or sign informed consent.
(11)Preexisting neuropathy > grade I NCI-CTC.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified