Choline Quantification in Breast Cancer by MRS

Withdrawn

• Conditions: Breast Neoplasms

• Registration Number: NCT00201487
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration.

The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS

Detailed Description

1. Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously.

2. Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference.

Both calculations can be performed from the same MR exam. Ten patients will be included in the study.

Study Timeline

• Study First Submitted: 2005-09-16
• Study First Submitted QC: 2005-09-16
• Study First Posted: 2005-09-20
• Study Start: 2007-11
• Primary Completion: 2007-11
• Study Completion: 2007-11
• Status Verified: 2013-10
• Last Update Submitted: 2013-10-30
• Last Update Posted: 2013-10-31

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• breast cancer

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified