Based on fNIRS to explore the brain effect mechanism of Jing-point health exercises in the treatment of mild cognitive impairment
- Conditions
- Mild cognitive impairment
- Registration Number
- ITMCTR2100004510
- Lead Sponsor
- Tianjin University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) It accords with the diagnostic criteria of amnesia mild cognitive impairment;
(2) Aged 55 to 75 years;
(3) The chief complaint includes subjective sensory memory loss;
(4) Objective examination showed memory loss and cognitive changes: the MoCA score was less than 26 (180.25). If the length of education was less than 12 years, the score would be added to the score of; MMSE (24,29). The AVLT score was below 1.5 standard deviations of age and education (55-59 <= 4, 60-69 <= 3, 70-75 <= 2);
(5) The (CDR) score of the Clinical dementia rating scale was 0.5 or the (GDS) score of the Comprehensive decline scale was 2 or 3, which did not meet the diagnostic criteria of dementia in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders revised version IV (DSM-IV-R);
(6) Activities of daily living scale (ADL) evaluation of activities of daily living is basically normal, independent living function is complete;
(7) Did not take drugs to improve mental or motor disorders;
(8) The subjects are primary school grade 6 or above, have the ability to complete the cognitive ability test and other tests stipulated in the program, and have the ability and time to complete the prescribed aerobics training;
(9) Did not engage in regular exercise in the past three months (that is, at least 3 times a week, each time at least 20 minutes of various forms of regular exercise);
(10) The subjects informed consent and volunteered to participate.
(1) The Hachinsk ischemia index scale (HIS) score was > 4;
(2) Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, g - disease, huntington's chorea, DLB and Parkinson's disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), important body disease (hepatic encephalopathy, pulmonary encephalopathy), intracranial space-occupying lesions (a subdural hematoma, brain tumor), the endocrine system lesion (thyroid disease, parathyroid disease), and vitamins or other cognitive causes of dementia;
(3) A history of neurological diseases (including stroke, optic neuromyelitis, epilepsy, Parkinson's disease, etc.);
(4) Psychiatric patients, dSM-IV criteria for schizophrenia or other psychiatric disorders, bipolar affective disorder, major depression or delirium;
(Hamilton anxiety scale (HAMA) assessment, scoring > 6;
Hamilton depression scale (HAMD) had 21 evaluations, scoring > 8 points.
(5) Abnormal laboratory indicators: liver function (ALT or AST) is 1.5 times higher than the upper limit of the normal range; Cr is 1.5 times higher than the upper limit of the normal range; anemia is moderate or above; fasting blood glucose value is 1.5 times higher than the upper limit of the normal range;
(6) Unstable or severe heart, lung, liver, kidney, hematopoietic diseases;
Severe diseases with poor prognosis, such as malignant tumors, have been informed;
(7) The presence of uncorrectable visual and auditory disorders can not complete the scale and other relevant tests;
(8) A history of serious alcohol and drug abuse within two years.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hemoglobin content;Montreal Cognitive Assessment Scale;
- Secondary Outcome Measures
Name Time Method Auditory Verb Learning test;mini-mental state examination;