ITMCTR2100004510
Recruiting
Phase 1
Based on fNIRS to explore the brain effect mechanism of Jing-point health exercises in the treatment of mild cognitive impairment
Tianjin University of Traditional Chinese Medicine0 sitesTBD
ConditionsMild cognitive impairment
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Mild cognitive impairment
- Sponsor
- Tianjin University of Traditional Chinese Medicine
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(1\) It accords with the diagnostic criteria of amnesia mild cognitive impairment;
- •(2\) Aged 55 to 75 years;
- •(3\) The chief complaint includes subjective sensory memory loss;
- •(4\) Objective examination showed memory loss and cognitive changes: the MoCA score was less than 26 (180\.25\). If the length of education was less than 12 years, the score would be added to the score of; MMSE (24,29\). The AVLT score was below 1\.5 standard deviations of age and education (55\-59 \<\= 4, 60\-69 \<\= 3, 70\-75 \<\= 2\);
- •(5\) The (CDR) score of the Clinical dementia rating scale was 0\.5 or the (GDS) score of the Comprehensive decline scale was 2 or 3, which did not meet the diagnostic criteria of dementia in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders revised version IV (DSM\-IV\-R);
- •(6\) Activities of daily living scale (ADL) evaluation of activities of daily living is basically normal, independent living function is complete;
- •(7\) Did not take drugs to improve mental or motor disorders;
- •(8\) The subjects are primary school grade 6 or above, have the ability to complete the cognitive ability test and other tests stipulated in the program, and have the ability and time to complete the prescribed aerobics training;
- •(9\) Did not engage in regular exercise in the past three months (that is, at least 3 times a week, each time at least 20 minutes of various forms of regular exercise);
- •(10\) The subjects informed consent and volunteered to participate.
Exclusion Criteria
- •(1\) The Hachinsk ischemia index scale (HIS) score was \> 4;
- •(2\) Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, g \- disease, huntington's chorea, DLB and Parkinson's disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), important body disease (hepatic encephalopathy, pulmonary encephalopathy), intracranial space\-occupying lesions (a subdural hematoma, brain tumor), the endocrine system lesion (thyroid disease, parathyroid disease), and vitamins or other cognitive causes of dementia;
- •(3\) A history of neurological diseases (including stroke, optic neuromyelitis, epilepsy, Parkinson's disease, etc.);
- •(4\) Psychiatric patients, dSM\-IV criteria for schizophrenia or other psychiatric disorders, bipolar affective disorder, major depression or delirium;
- •(Hamilton anxiety scale (HAMA) assessment, scoring \> 6;
- •Hamilton depression scale (HAMD) had 21 evaluations, scoring \> 8 points.
- •(5\) Abnormal laboratory indicators: liver function (ALT or AST) is 1\.5 times higher than the upper limit of the normal range; Cr is 1\.5 times higher than the upper limit of the normal range; anemia is moderate or above; fasting blood glucose value is 1\.5 times higher than the upper limit of the normal range;
- •(6\) Unstable or severe heart, lung, liver, kidney, hematopoietic diseases;
- •Severe diseases with poor prognosis, such as malignant tumors, have been informed;
- •(7\) The presence of uncorrectable visual and auditory disorders can not complete the scale and other relevant tests;
Outcomes
Primary Outcomes
Not specified
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