ITMCTR2100004510招募中1 期
Based on fNIRS to explore the brain effect mechanism of Jing-point health exercises in the treatment of mild cognitive impairment
Tianjin University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 55 至 75（—）
- 性别
- All
入选标准
- •(1) It accords with the diagnostic criteria of amnesia mild cognitive impairment;
- •(2) Aged 55 to 75 years;
- •(3) The chief complaint includes subjective sensory memory loss;
- •(4) Objective examination showed memory loss and cognitive changes: the MoCA score was less than 26 (180.25). If the length of education was less than 12 years, the score would be added to the score of; MMSE (24,29). The AVLT score was below 1.5 standard deviations of age and education (55-59 <= 4, 60-69 <= 3, 70-75 <= 2);
- •(5) The (CDR) score of the Clinical dementia rating scale was 0.5 or the (GDS) score of the Comprehensive decline scale was 2 or 3, which did not meet the diagnostic criteria of dementia in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders revised version IV (DSM-IV-R);
- •(6) Activities of daily living scale (ADL) evaluation of activities of daily living is basically normal, independent living function is complete;
- •(7) Did not take drugs to improve mental or motor disorders;
- •(8) The subjects are primary school grade 6 or above, have the ability to complete the cognitive ability test and other tests stipulated in the program, and have the ability and time to complete the prescribed aerobics training;
- •(9) Did not engage in regular exercise in the past three months (that is, at least 3 times a week, each time at least 20 minutes of various forms of regular exercise);
- •(10) The subjects informed consent and volunteered to participate.
排除标准
- •(1) The Hachinsk ischemia index scale (HIS) score was > 4;
- •(2) Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, g - disease, huntington's chorea, DLB and Parkinson's disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), important body disease (hepatic encephalopathy, pulmonary encephalopathy), intracranial space-occupying lesions (a subdural hematoma, brain tumor), the endocrine system lesion (thyroid disease, parathyroid disease), and vitamins or other cognitive causes of dementia;
- •(3) A history of neurological diseases (including stroke, optic neuromyelitis, epilepsy, Parkinson's disease, etc.);
- •(4) Psychiatric patients, dSM-IV criteria for schizophrenia or other psychiatric disorders, bipolar affective disorder, major depression or delirium;
- •(Hamilton anxiety scale (HAMA) assessment, scoring > 6;
- •Hamilton depression scale (HAMD) had 21 evaluations, scoring > 8 points.
- •(5) Abnormal laboratory indicators: liver function (ALT or AST) is 1.5 times higher than the upper limit of the normal range; Cr is 1.5 times higher than the upper limit of the normal range; anemia is moderate or above; fasting blood glucose value is 1.5 times higher than the upper limit of the normal range;
- •(6) Unstable or severe heart, lung, liver, kidney, hematopoietic diseases;
- •Severe diseases with poor prognosis, such as malignant tumors, have been informed;
- •(7) The presence of uncorrectable visual and auditory disorders can not complete the scale and other relevant tests;
- •(8) A history of serious alcohol and drug abuse within two years.
研究者
相似试验
尚未招募
1 期
Based on EEG and fMRI technology to investigate the transdermal acupoint stimulation mechanism researchhealthy subjectsITMCTR2200006101Xuzhou Rehabilitation Hospital
招募中
不适用
Investigation of the effects of non-invasive brain stimulation over the dorsolateral prefrontal cortex on tactile orientation discrimination ability.healthy personsJPRN-UMIN000046297iigata University of Health and Welfare40
已完成
不适用
Investigation of the effects of non-invasive brain stimulation on brain oscillations and plasticityneurological diseasesJPRN-UMIN000044806iigata University of Health and Welfare200
招募中
不适用
Investigation of the effects of non-invasive brain stimulation over the bilateral posterior parietal cortex on tactile orientation discrimination ability.healthy personsJPRN-UMIN000046595iigata University of Health and Welfare30
招募中
不适用
Neural Bases of Social Cognitive Processing in Healthy IndividualsHealthy VolunteersNCT05774860Istituti Clinici Scientifici Maugeri SpA200