Association of Hypoxia Measured by Oxygen Desaturation Index (ODI) in OSA with Delis-Kaplan Executive Function System (D-KEFS) Tests in Middle-Aged and Older Adults

Not Applicable

Recruiting

• Conditions: Obstructive sleep apnea; Cognitive impairment; Memory; Executive function; Elderly; Magnetic resonance imaging

• Registration Number: TCTR20190805004
• Lead Sponsor: Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-05
• Study Completion: 2019-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

1. Newly diagnosed with moderate to severe OSA by a split-night laboratory polysomnography (apnea hypopnea index ≥ 15)

Exclusion Criteria

1.Severe systemic diseases : cirrhosis (Child-Pugh score B or C), chronic kidney disease stage 3 or more, pulmonary disease with chronic hypoxia or hypercarbia, heart failure NYHA II or more
2.Psychiatric illness
3.Neurological diseases : brain tumor, stroke, epilepsy, coma, history loss of consciousness of more than 30 mins after head trauma, encephalitis
4.Use of psychotropic medications
5.Alcohol or illicit drug abuse
6.Prior therapy for OSA
7.Sleep disorders other than OSA including central sleep apnea, insomnia, REM behavioral disorder, restless leg syndrome, periodic limb movement disorder, narcolepsy
8.Thai Mental State Examination score < 24
9.Inability to complete neuropsychological assessments or not fluent in Thai
10.Contraindications for MRI: presence of cardiac pacemaker or defibrillator, presence of metallic implants, claustrophobia, or uncomfortable or unable to lie down still for the MRI.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of oxygen desaturation index and score from D-KEFS Tower Test Once after diagnosed with OSA D-KEFS Tower Test