Study of MEDI-524 (Motavizumab) for the Prophylaxis of Serious Respiratory Syncytial Virus (RSV) Disease in High-Risk Children
- Conditions
- Respiratory Syncytial Virus Infections
- Interventions
- Biological: palivizumabBiological: motavizumab (MEDI-524)
- Registration Number
- NCT00129766
- Lead Sponsor
- MedImmune LLC
- Brief Summary
The primary objective of this study was to compare the safety and efficacy of motavizumab to palivizumab when administered monthly by intramuscular (IM) injection for the reduction of the incidence of RSV hospitalization among children at high risk for serious RSV disease. A secondary objective was to compare the incidence of medically-attended lower respiratory infections (LRIs) between treatment groups.
- Detailed Description
A randomized, double-blind, palivizumab-controlled, multi-center, multi-national trial conducted during 2 Northern Hemisphere RSV seasons with an intervening season in the Southern Hemisphere. Each child only participated during a single RSV season. Approximately 6,600 children at risk for serious RSV disease were to be randomized in a 1:1 ratio to receive either 15 mg/kg of palivizumab or motavizumab by IM injection every 30 days for a total of 5 doses.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6635
- 24 months of age or younger at randomization (child must be randomized on or before his/her 24-month birthday) with a diagnosis of chronic lung disease (CLD) of prematurity requiring medical intervention/management (i.e., supplemental oxygen, bronchodilators, or diuretics) within 6 months before randomization
OR:
- 35 weeks gestational age or less at birth and 6 months of age or younger at randomization (children were to be randomized on or before his/her 6-month birthday)
- Hospitalization at the time of randomization (unless discharge was anticipated within 10 days)
- Mechanical ventilation or other mechanical support (including continuous positive airways pressure [CPAP])
- Life expectancy < 6 months
- Active RSV infection (a child with signs/symptoms of respiratory infection must have had negative RSV testing)
- Known renal impairment
- Known hepatic dysfunction
- Chronic seizure or evolving or unstable neurologic disorder
- Congenital heart disease [CHD] (children with uncomplicated CHD [e.g., patent ductus arterious (PDA), small septal defect] and children with complicated CHD that were currently anatomically and hemodynamically normal could be enrolled)
- Known immunodeficiency
- Mother with HIV infection (unless the child has been proven to be not infected)
- Known allergy to Ig products
- Receipt of palivizumab, RSV-IGIV, or other RSV-specific monoclonal antibody, or any other polyclonal antibody (for example, hepatitis B IG, IVIG, VZIG) within 3 months prior to randomization
- Anticipated use of palivizumab or IVIG during the study (blood transfusions permitted)
- Previous receipt of RSV vaccines
- Participation in other investigational drug product studies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description palivizumab palivizumab 15 mg/kg administered intramuscularly for 5 monthly doses motavizumab (MEDI-524) motavizumab (MEDI-524) 15 mg/kg of motavizumab was administered intramuscularly for 5 monthly doses
- Primary Outcome Measures
Name Time Method Number of Participants Who Discontinued Study Drug Due to AEs Days 0 - 150 Number of Participants Reporting Any Serious Adverse Events (SAEs) Days 0 - 150 Number of participants reporting one or more SAEs
Number of Participants Reporting Changes in Vital Signs From Baseline Days 0 - 150 Vital signs that were in a higher toxicity grade than observed at baseline were to be recorded as AEs
Number of Participants Reporting Any Adverse Events (AEs) Days 0 - 150 Number of participants reporting one or more AEs
Number of Participants Reporting Any Related SAEs Days 0 - 150 Number of participants reporting one or more SAEs considered related to study drug by the investigator
Incidence of RSV Hospitalization (Includes Deaths by RSV) Days 0 - 150 RSV hospitalization was defined as 1) a respiratory hospitalization with a positive RSV test (primary), 2) a new onset of lower respiratory symptoms in an already hospitalized child, with an objective measure of worsening respiratory status and positive RSV test (nosocomial), or 3) death demonstrated to have been caused by RSV (by autopsy or clinical history and virologic evidence).
Number of Participants Reporting Any Related AEs Days 0 - 150 Number of participants reporting one or more AEs considered related to study drug by the investigator
Number of Participants Reporting AEs by Highest Severity Grade Days 0 - 150 Adverse events events were graded by severity; Level 1, 2, 3, or 4
Number of Participants Who Died Days 0 - 150
- Secondary Outcome Measures
Name Time Method The Number of Participants With Anti-motavizumab Antibodies Day 0 - 120 Detection of anti-motavizumab antibodies was defined as a titer with a dilution value equal to or greater than 1:10.
The Incidence of Outpatient Medically-attended Lower Respiratory Illness (LRI) Day 0 - 150 LRI was defined as an event of bronchiolitis or pneumonia or the occurance of a lower tract infectious illness as determined by the PI based on medical history, signs, and symptoms.
The Trough Serum Concentrations of Motavizumab at 30 Days Post Dose 2 30 days post Dose 2 Mean serum concentrations of motavizumab at 30 days post Dose 2
The Trough Serum Concentrations of Motavizumab at 30 Days Post Dose 4 30 days post Dose 4 Mean serum concentrations of motavizumab at 30 days post Dose 4
The Incidence of Medically-attended Otitis Media (OM) Infections Days 0 - 150 Otitis media (OM) was to be recorded as the diagnosis if the following terms were used by the medical care provider: acute OM, acute tympanic membrane (TM) perforation, bulging TM, red TM with fever, OM with effusion, or middle ear effusion. A new episode was defined as a physician-diagnosed OM in either ear after a normal middle ear exam of the ear in question or an episode of acute OM greater than or equal to 21 days after resolution of the previous episode. A diagnosis of persistent middle ear effusion was not to be recorded as a new OM event.
The Frequency of Prescribed Antibiotics for Medically-attended LRI Days 0 - 150 The average number of presciptions per event per subject was summarized for each treatment group.
The Frequency of Prescribed Antibiotics for Medically-attended OM Infections Days 0 - 150 The average number of presciptions per event per subject was summarized for each treatment group.
The Serum Concentrations of Motavizumab at Day 0 Day 0 Mean serum concentrations of motavizumab at Day 0
The Incidence of RSV-specific Medically-attended Outpatient Lower Respiratory Illnesses (LRIs) Between Treatment Groups Days 0 - 150 The RSV-specific LRI was defined as an outpatient medically-attended LRI associated with a positive RSV test and was not inclusive of events that required hospitalization.
The Trough Serum Concentrations of Motavizumab at 30 Days Post Dose 1 30 days post Dose 1 Mean serum concentrations of motavizumab at 30 days post Dose 1
The Trough Serum Concentrations of Motavizumab at 30 Days Post Dose 3 30 days post Dose 3 Mean serum concentrations of motavizumab at 30 days post Dose 3
Trial Locations
- Locations (342)
Kaiser Permanente Los Angeles
🇺🇸Los Angeles, California, United States
Emory University School Of Medicine
🇺🇸Atlanta, Georgia, United States
Lehigh Valley Hospital
🇺🇸Allentown, Pennsylvania, United States
Driscoll Children's Hospital
🇺🇸Corpus Christi, Texas, United States
Saint Barnabas Medical Center
🇺🇸Livingston, New Jersey, United States
Geisinger Medical Center- JW Children's Hospital
🇺🇸Danville, Pennsylvania, United States
Jefferson-duPont Children's Health Program
🇺🇸Philadelphia, Pennsylvania, United States
Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
Univ. Of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Pediatric Clinical Trials International, Inc.
🇺🇸Columbus, Ohio, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Hospital Maternal Virgen del Rocío
🇪🇸Sevilla, Spain
Children's Memorial Hospital
🇺🇸Chicago, Illinois, United States
Metro Health Medical Center
🇺🇸Cleveland, Ohio, United States
University of Virginia Hospital
🇺🇸Charlottesville, Virginia, United States
Children's Corporate Center
🇺🇸Wauwatosa, Wisconsin, United States
Hospital Sao Lucas da PUC-RS de Riberiao Perto da Universidade de Sao Paulo
🇧🇷Porto Alegre, Brazil
Children's Hospital of Eastern Ontario
🇨🇦Ottawa, Canada
Hospital San Jose
🇨🇱Independencia, Chile
Hospital Dr. Feliz Buines Cerda
🇨🇱Quinta Normal, Chile
Hospital Clinico San Borja Arriaran
🇨🇱Santiago, Chile
Fakultni nemocnice
🇨🇿Olomouc, Czech Republic
FNsP Ostrava
🇨🇿Ostrava, Czech Republic
CHU Rouen
🇫🇷Rouen Cedex, France
CH Pierre Haute
🇫🇷Strasbourg, France
Ruhr-Uni St. Josef Hospital
🇩🇪Bochum, Germany
Im Neuenheimer Feld 153
🇩🇪Heidelberg, Germany
Stadtisches Krankenhaus Muchen-Harlaching
🇩🇪Munchen, Germany
Kinderklinik und Kinderpoliklinik
🇩🇪Muenchen, Germany
Wolfson Medical Center
🇮🇱Holon, Israel
Ospedali Riuniti di Bergamo - Azienda Ospedaliera/Unità Operativa di Patologia Neonatale
🇮🇹Bergamo, Italy
Poria Medical Center
🇮🇱Tiberia, Israel
Azienda USL di Imola - Ospedale di Imola
🇮🇹Imola, Italy
Azienda Ospedaliera Universitaria Policlinico Gaetano Martino
🇮🇹Messina, Italy
Ospedale Alessandro Manzoni Lecco - Presidio dell'Azienda Ospedaliera "Ospedale di Lecco"
🇮🇹Lecco, Italy
Azienda Ospedaliera San Gerardo
🇮🇹Monza, Italy
University Of Miami Medical Center
🇺🇸Miami, Florida, United States
James Whitcomb Riley Hospital for Children
🇺🇸Indianapolis, Indiana, United States
Texas Children's Hospital
🇺🇸Houston, Texas, United States
University Of Texas Houston Medical School
🇺🇸Houston, Texas, United States
"P&A Kyriakou" Children's hospital
🇬🇷Athens, Greece
Hospital Dr. Sotero Del Rio
🇨🇱Puente Alto, Chile
Hospital Padre Hurtado
🇨🇱Santiago, Chile
Nemocnice CB
🇨🇿Ceske Budejovice, Czech Republic
University of California
🇺🇸San Diego, California, United States
Children's Hospital San Diego
🇺🇸San Diego, California, United States
Children's Lung Specialist, Ltd
🇺🇸Las Vegas, Nevada, United States
University of Cincinnati Col. of Med.
🇺🇸Cincinnati, Ohio, United States
Hospital De Clinicas Da UFPR
🇧🇷Curitiba, Brazil
LandesKrankenHaus Tulln, Kinderabteilung
🇦🇹Tulln, Austria
VCU Medical Center
🇺🇸Richmond, Virginia, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
University Of Texas Health Science Center
🇺🇸San Antonio, Texas, United States
California Pacific Medical Center
🇺🇸San Francisco, California, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Primary Children's Medical Center
🇺🇸Salt Lake City, Utah, United States
Maricopa Medical Center
🇺🇸Phoenix, Arizona, United States
Children's Hospital Of Michigan
🇺🇸Detroit, Michigan, United States
St. John Hospital & Medical Center
🇺🇸Detroit, Michigan, United States
Children's Hospital Of Oklahoma
🇺🇸Oklahoma City, Oklahoma, United States
University Of Alabama At Birmingham
🇺🇸Birmingham, Alabama, United States
Children's Hospital
🇺🇸Denver, Colorado, United States
Univ. S. Florida Pediatrics Ambulatory Care Center
🇺🇸Tampa, Florida, United States
University of Michigan Mott Children's Hospital
🇺🇸Ann Arbor, Michigan, United States
University of Nebraska Medical Center Pediatric
🇺🇸Omaha, Nebraska, United States
Wake Forest University School of Medicine
🇺🇸Winston-Salem, North Carolina, United States
Oregon Health Sciences University
🇺🇸Portland, Oregon, United States
St. Joseph's Hospital
🇺🇸Milwaukee, Wisconsin, United States
University of Pecs
🇭🇺Pecs, Hungary
Univ. of Pecs
🇭🇺Pecs, Hungary
Central Arkansas Pediatric Clinic, PA
🇺🇸Benton, Arkansas, United States
Alabama Neonatal Medicine OC
🇺🇸Pike Road, Alabama, United States
The Children's Clinic Of Jonesboro, P.A.
🇺🇸Jonesboro, Arkansas, United States
Little Rock Children's Clinic, PA
🇺🇸Little Rock, Arkansas, United States
Arkansas Children's Hospital Research Institute
🇺🇸Little Rock, Arkansas, United States
Arkansas Pediatric Clinic
🇺🇸Little Rock, Arkansas, United States
Miller Children's Hospital
🇺🇸Long Beach, California, United States
Children's Hospital of Oakland
🇺🇸Oakland, California, United States
Kaiser Permanente Health Care Plan
🇺🇸Oakland, California, United States
Children's Hospital of Orange County
🇺🇸Orange, California, United States
Santa Clara Valley Medical Center
🇺🇸San Jose, California, United States
Connecticut Children's Medical Center
🇺🇸Hartford, Connecticut, United States
Pediatric Pulmonology, LLC
🇺🇸Stamford, Connecticut, United States
A. I. Dupont Hospital For Children
🇺🇸Wilmington, Delaware, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
The Nemours Children's Clinic
🇺🇸Jacksonville, Florida, United States
Georgia Pediatric Pulmonology Associates
🇺🇸Atlanta, Georgia, United States
University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States
Lutheran General Children's Hospital
🇺🇸Park Ridge, Illinois, United States
Advocate Hope Children's Hospital
🇺🇸Cook, Illinois, United States
Memorial Hospital of South Bend
🇺🇸South Bend, Indiana, United States
Tufts-New England Medical Center
🇺🇸Boston, Massachusetts, United States
Louisiana State University MidCity Clinic
🇺🇸Baton Rouge, Louisiana, United States
Baystate Medical Center
🇺🇸Springfield, Massachusetts, United States
University Of Maryland School of Medicine
🇺🇸Baltimore, Maryland, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
St. Mary's Duluth Clinic
🇺🇸Duluth, Minnesota, United States
DeVos Children's Hospital
🇺🇸Grand Rapids, Michigan, United States
Children's Healthcare D.B.A. Hospitals & Clinics
🇺🇸St. Paul, Minnesota, United States
Albany Medical Center
🇺🇸Albany, New York, United States
New Jersey Medical School
🇺🇸Newark, New Jersey, United States
Dartmouth Medical School
🇺🇸Lebanon, New Hampshire, United States
Women & Children's Hospital
🇺🇸Buffalo, New York, United States
Winthrop University Hospital
🇺🇸Mineola, New York, United States
University Of Rochester Medical Center
🇺🇸Rochester, New York, United States
Schneider Children's Hospital
🇺🇸New Hyde Park, New York, United States
The Children's Medical Group
🇺🇸Poughkeepsie, New York, United States
Crouse Hospital NICU
🇺🇸Syracuse, New York, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
Carolinas Medical Center
🇺🇸Charlotte, North Carolina, United States
Beehly Medical Park Women's and Children's Pav.
🇺🇸Boardman, Ohio, United States
Raleigh Pediatric Associates
🇺🇸Raleigh, North Carolina, United States
East Carolina University School of Medicine
🇺🇸Greenville, North Carolina, United States
Children's Medical Center
🇺🇸Dayton, Ohio, United States
Tod Children's Hospital
🇺🇸Mahaning, Ohio, United States
St. Vincent Medical Center
🇺🇸Toledo, Ohio, United States
Toledo Children's Hospital
🇺🇸Toledo, Ohio, United States
St. Luke's Hospital
🇺🇸Bethlehem, Pennsylvania, United States
Bryn Mawr Hospital
🇺🇸Bryn Mawr, Pennsylvania, United States
The Children's Hospital Of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Children's Hospital of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Lebonheur Children's Medical Center
🇺🇸Memphis, Tennessee, United States
Sioux Valley Hospital University of South Dakota Medical Center
🇺🇸Sioux Falls, South Dakota, United States
Texas Tech Health Sciences Center
🇺🇸Lubbock, Texas, United States
University Physicians
🇺🇸Huntington, West Virginia, United States
Marshfield Clinic
🇺🇸Marshfield, Wisconsin, United States
Waukesha Memorial Hospital, Inc
🇺🇸Waukesha, Wisconsin, United States
Hospital Peiade Interzonal General de Augodos
🇦🇷Buenos Aires, Argentina
Hospital General De Ninos Pedro De Elizalde
🇦🇷Buenos Aires, Argentina
Sanatorio Trinidad
🇦🇷Capital Federal, Argentina
Hospital Materno Neonatal
🇦🇷Cordoba, Argentina
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Royal Children's Hospital (Brisbane)
🇦🇺Herston, Queensland, Australia
The Canberra Hospital
🇦🇺Garran, Australian Capital Territory, Australia
John Hunter Children's Hospital
🇦🇺New Lambton, New South Wales, Australia
Peninsula Clinical Research Centre
🇦🇺Kippa-Ring, Queensland, Australia
Mater Mothers Hospital Raymond Terrace
🇦🇺South Brisbane, Queensland, Australia
Royal Children's Hospital (Melbourne)
🇦🇺Parkville, Victoria, Australia
Royal Hobart Hospital
🇦🇺Hobart, Tasmania, Australia
Princess Margaret Children's Hospital
🇦🇺Subiaco, Western Australia, Australia
Women's and Children's Hospital
🇦🇺North Adelaide, Australia
Universitatsklinik fur Kinder und Jugenheilkunde, Graz
🇦🇹Graz, Austria
SMZ-Ost Donauspital Wien
🇦🇹Wien, Austria
Allgemeines KrankenHaus Universitatsklinkiken Wein
🇦🇹Wien, Austria
Hospital e Maternidade Celso Pierro-Puccamp
🇧🇷Campinas, Brazil
Santa Casa de Misericordia de Sao Paulo
🇧🇷Sao Paulo, Brazil
Hospital e Maternidade Santa Marina
🇧🇷Sao Paulo, Brazil
Hospital Universitario de Universidade de Sao Paulo
🇧🇷Sao Paulo, Brazil
Mernidade Nossa Senhora De Fatima
🇧🇷Curitiba, Brazil
Hospital Das Clinicas Da Faculdade De Medicina
🇧🇷Ribeirao Preto, Brazil
Multifunctional Hospital for Active Treatment "Pleven"
🇧🇬Pleven, Bulgaria
University Multifunctional Hospital for Active Treatment "St. George" Neonatology Clinic
🇧🇬Plovdiv, Bulgaria
University Multifunctional Hospital for Active Treatment "St. George" Clinic of Pediatrics
🇧🇬Plovdiv, Bulgaria
Multifunctional Hospital for Active Treatment - Plovdiv
🇧🇬Plovdiv, Bulgaria
Regional Hospital of Pulmonary Diseases
🇧🇬Rousse, Bulgaria
Specialized Hospital for Active Treatment of Cardio-vascular Diseases
🇧🇬Sofia, Bulgaria
Dalhousie University IWK Health Centre
🇨🇦Halifax, Canada
Sainte Justine Hospital
🇨🇦Montreal, Canada
Specialized Hospital for Active Treatment of Pediatric Diseases
🇧🇬Sofia, Bulgaria
Multifunctional Hospital for Active Treatment "St. Marina"
🇧🇬Varna, Bulgaria
Specialized Hospital for Active Treatment of Obstetrics and Gynaecology"-"Maichin Dom"
🇧🇬Sofia, Bulgaria
Alberta Children's Hospital
🇨🇦Calgary, Canada
University Of Alberta/Stollery Children's Hospital
🇨🇦Edmonton, Canada
Queen Elizabeth Hospital
🇨🇦Charlottetown, Canada
Centre Hospitalier de L'Universite Laval
🇨🇦Quebec City, Canada
McGill University Health Centre Monteal Children's Hospital
🇨🇦Montreal, Canada
Royal University Hospital
🇨🇦Saskatoon, Canada
Mcmaster Children's Hospital
🇨🇦Hamilton, Canada
Children's And Women's Hospital of BC
🇨🇦Vancouver, Canada
Victoria General Hospital
🇨🇦Victoria, Canada
Windsor Regional Hospital
🇨🇦Windsor, Canada
Hospital Clinico de la Universidad de Chile
🇨🇱Independencia, Chile
Manitoba Institute Of Child Health University of Manitoba
🇨🇦Winnipeg, Canada
FN Hradec Kralove Detska klinika
🇨🇿Hradec Kralove, Czech Republic
Nemocnice s poliklinikou v Moste
🇨🇿Most, Czech Republic
FN Plzen
🇨🇿Plzen-Lochotin, Czech Republic
Vfn 1.Lf Uk
🇨🇿Praha 2, Czech Republic
Fakultni Thomayerova nemocnice S poliklinkou
🇨🇿Praha 4, Czech Republic
Ustav pro peci o matku a dite
🇨🇿Praha 4, Czech Republic
FN Motol Novorozenecke oddeleni
🇨🇿Praha 5, Czech Republic
Batova krajska nemocnice Zlin
🇨🇿Zlin, Czech Republic
Paediatrisk Afdeling Herning Centralsygehus
🇩🇰Herning, Denmark
Hvidovre Hospital
🇩🇰Hvidovre, Denmark
Hillerod Sygehus Helsevej 2
🇩🇰Hillerod, Denmark
Sygehus Viborg
🇩🇰Viborg, Denmark
Service de Medecine Neonatale et de reanimation pediatrique
🇫🇷Amiens Cedex 1, France
CH Chambery
🇫🇷Chambery, France
CHU Bordeaux/Hopital des enfants/Unite de Neonatologie B
🇫🇷Bordeaux, France
CHU Angers
🇫🇷Angers, France
Hopital Jeanne de Flandre
🇫🇷Lille, France
CHU Dijon
🇫🇷Dijon, France
CHU de Besancon-Hopital Saint-Jacques
🇫🇷Besancon, France
CHI Poissy/St Germain en Laye
🇫🇷Poissy Cedex, France
CHU Rennes/Hopital Sud
🇫🇷Rennes Cedex, France
CHU Nord
🇫🇷Marseille, France
CHU de Nantes/Hospital Mere-Enfant
🇫🇷Nantes, France
CHU Montpellier/Hoptial Arnaud de Villeneuve
🇫🇷Montpellier, France
Centre Pediatrique Gatien de Clocheville
🇫🇷Tours Cedex, France
Klinikum Duisburg, Wedau Kliniken
🇩🇪Duisburg, Germany
Uni-Kinderklinik
🇩🇪Dusseldorf, Germany
CHU Toulouse-Hopital des Enfants
🇫🇷Toulouse Cedex 9, France
Zentrum Klinische Studien/Universtatsklinikum Freiburg
🇩🇪Freiburg, Germany
Klinik fur Kinder und Jugendliche
🇩🇪Erlangen, Germany
Wittenberg/Zentrum: fur Kinderheilkunde, Universitatsklinik und Poliklinik fur Kinder and Jugendmedizin
🇩🇪Halle, Germany
Universtatsklinikum Gottingen
🇩🇪Gottingen, Germany
Stiftung Hannoversche
🇩🇪Hannover, Germany
Klinik und Poliklinik und Jugendiche der Universitat Leipzig
🇩🇪Leipzig, Germany
Universitatskinderlinik/Zentrum Fur klinische Studien
🇩🇪Mainz, Germany
Evangelischisches Krankenhaus
🇩🇪Oberhausen, Germany
Klinikum Oldenberg
🇩🇪Oldenberg, Germany
Klinikum Rosenheim
🇩🇪Rosenheim, Germany
Asklepios Kinderklinik Sankt Augustin GmbH
🇩🇪Sankt Augustin, Germany
Aghia Sofia Children hospital
🇬🇷Athens, Greece
Aristotele University of Thessaloniki, General "AXEPA" Hospital
🇬🇷Thessaloniki, Greece
Semmelweis University
🇭🇺Budapest, Hungary
General hospital "Papageorgiou"
🇬🇷Thessaloniki, Greece
Hippokration Hospital, University of Thessaloniki
🇬🇷Thessaloniki, Greece
Schopf-Merei Agost Hospital
🇭🇺Budapest, Hungary
Semmelweis Univ.
🇭🇺Budapest, Hungary
DEOEC Neonatology Division
🇭🇺Debrecen, Hungary
DEOEC, Dept. of Pediatry
🇭🇺Debrecen, Hungary
Petz Aladar Teaching Hospital
🇭🇺Gyor, Hungary
Josa Andras Hospital
🇭🇺Nyiregyhaza, Hungary
Csolnoky Ferenc Hospital
🇭🇺Veszprem, Hungary
Borsod-Abaúj-Zemplén Megyei Önkormányzat Kórháza
🇭🇺Miskolc, Hungary
Children's hospital, Landspitali University Hospital
🇮🇸Reykjavik, Iceland
HaEmek Medical Center
🇮🇱Afula, Israel
Bnei Zion Medical Center
🇮🇱Haifa, Israel
Barzilai Medical Center
🇮🇱Ashkelon, Israel
Soroka Medical Center
🇮🇱Beer-Sheva, Israel
Rambam Medical Center
🇮🇱Haifa, Israel
Carmel Medical Center
🇮🇱Haifa, Israel
Hadassah Ein-Kerem Medical Center
🇮🇱Jerusalem, Israel
Sapir Medical Center
🇮🇱Kfar-Saba, Israel
Laniado Medical Center
🇮🇱Natanya, Israel
Schneider Medical Center
🇮🇱Petach Tikva, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Chaim Sheba Medical Center
🇮🇱Tel-Hashomer, Israel
Sourasky Medical Center (Ichilov)
🇮🇱Tel-Aviv, Israel
Presio Ospedaliero di Alta Specializzazione "G. Salesi" - Azienda Ospedaliera Universitaria - Ospedali Riuniti "Umberto I - G.M. Lancisi - G. Salesi"
🇮🇹Ancona, Italy
Azienda Ospedaliera di Bologna - Policlinico S. Orsola - Malpighi
🇮🇹Bologna, Italy
Ospedale Generale di Bolzano
🇮🇹Bolzano, Italy
Spedali Civili di Brescia
🇮🇹Brescia, Italy
Azienda Ospedaliera Universitaria
🇮🇹Foggia, Italy
Azienda Ospedaliera S. Croce e Carle
🇮🇹Cuneo, Italy
Azienda Ospedaliera Universitaria Pisana - Ospedale S. Chiara
🇮🇹Pisa, Italy
Azienda Sanitaria Ospedaliera O.I.R.M.-S. Anna
🇮🇹Torino, Italy
Azienda Ospedaliera di Parma
🇮🇹Parma, Italy
Middlemore Hospital
🇳🇿Auckland, New Zealand
Azienda Ospedaliera S. Maria della Misericordoa Struttura Operativa Complessa di Patologia Neonatale e terapia Intesiva Neonatale
🇮🇹Udine, Italy
Waikato Hospital
🇳🇿Hamilton, New Zealand
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Palmerston North Hospital
🇳🇿Palmerston North, New Zealand
Klinika Neonatologii AM w Białymstoku
🇵🇱Białystok, Poland
Oddział Pediatrii i Kardiologii z pododdziałem Patologii Noworodka
🇵🇱Bydgoszcz, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej Wojewódzki Szpital im. dr Jana Biziela w Bydgoszczy, Oddział Noworodków, Wcześniaków I Intensywnej Terapii Noworodka
🇵🇱Bydgoszcz, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1, Klinika Neonatologii
🇵🇱Gdańsk, Poland
Szpital Morski im. PCK, Oddział Dziecięcy
🇵🇱Gdynia, Poland
Wojewódzki Szpital Specjalistyczny, Oddział Dziecięcy
🇵🇱Częstochowa, Poland
Katedra i Klinika Neonatologii AM w Poznaniu
🇵🇱Poznań, Poland
Oddzial Kliniczny Kliniki Neonatologii Szpitala Uniwersyteckiego w Krakowie
🇵🇱Krakow, Poland
Dziecięcy Szpital Kliniczny im. Prof. dr hab. n. med. Antoniego Gębali w Lublinie
🇵🇱Lublin, Poland
Niepubliczny Zakład Opieki Zdrowotnej Salmed s.c.
🇵🇱Leczna, Poland
II Klinika Chorób Dzieci PAM, Samodzielny Publiczny
🇵🇱Szczecin, Poland
Klinika Neonatologii AM w Warszawie
🇵🇱Warsaw, Poland
Klinika Niemowlęca, Instytut Pomnik - Centrum Zdrowia Dziecka
🇵🇱Warszawa, Poland
Szpital Kliniczny nr 4 im.M.Konopnickiej, Oddział Intensywnej Terapii i Anestezjologii
🇵🇱Łódź, Poland
Klinika Neonatologii, Instytut Centrum Zdrowia Matki Polki
🇵🇱Łódź, Poland
Pediatric City Hospital #13
🇷🇺Moscow, Russian Federation
Morozovsky Pediatric City Hospital
🇷🇺Moscow, Russian Federation
Smolensk State Medical Academy
🇷🇺Smolensk, Russian Federation
St. Petersburg City Outpatient Hospital #45
🇷🇺St. Petersburg, Russian Federation
Saint-Petersburg State Pediatric Medical Academy
🇷🇺St. Petersburg, Russian Federation
St. Petersburg State Pediatric Medical Academy
🇷🇺St. Petersburg, Russian Federation
Hospital Clinic y Maternistat - Barcelona
🇪🇸Barcelona, Spain
Pediatric City Hospital #1
🇷🇺St. Petersburg, Russian Federation
Hospital de Cruces
🇪🇸Cruces, Spain
Hospital Reina Sofia
🇪🇸Córdoba, Spain
Hospital Sant Joan de Déu (Barcelona)
🇪🇸Barcelona, Spain
Hospital Josep Trueta
🇪🇸Gerona, Spain
Hospital de Donostia (San Sebastian)
🇪🇸Guipuzcoa, Spain
Hospital Virgen de las Nieves
🇪🇸Granada, Spain
Hospital Materno Infantil deJaén
🇪🇸Jaén, Spain
Hospital General de Jerez
🇪🇸Jerez, Spain
Hospital Juan Canalejo
🇪🇸La Coruña, Spain
Hospital Materno Infantil de Canarias
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Clínico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario de Canarias
🇪🇸Santa Cruz de Tenerife, Spain
Hospital Central de Asturias
🇪🇸Oviedo, Spain
Hospital Clinico de Salamanca
🇪🇸Salamanca, Spain
Hospital Materno Infantil/Neumología pediátrica
🇪🇸Malaga, Spain
Hospital La Paz- Madrid
🇪🇸Madrid, Spain
Hospital Clinico Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Xeral-Cíes
🇪🇸Vigo, Spain
Mälarsjukhuset
🇸🇪Eskilstuna, Sweden
Hospital Universitario La Fe Maternidad
🇪🇸Valencia, Spain
Hospital Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Joan XXIII
🇪🇸Tarragona, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Uppsala University Hospital
🇸🇪Uppsala, Sweden
The Queen Silvia Children's Hospital
🇸🇪Goteborg, Sweden
Karolinska University Hospital Solna
🇸🇪Stockholm, Sweden
Danderyds Sjukhus
🇸🇪Stockholm, Sweden
Hacettepe Üniversitesi İhsan Doğramacı Çocuk Hastanesi Neonatoloji Ünitesi
🇹🇷Ankara, Turkey
Ankara Üniversitesi
🇹🇷Ankara, Turkey
Birmingham Heartlands Hospital
🇬🇧Birmingham, United Kingdom
Ege Üniversitesi Tıp Fakültesi
🇹🇷Izmir, Turkey
Dokuz Eylül Üniversitesi Tıp Fakültesi
🇹🇷Izmir, Turkey
Children's Respiratory Medicine Division of Maternal and Child Health Sciences Ninewells Hospital
🇬🇧Dundee, United Kingdom
Medway Maritime Hospital
🇬🇧Gillingham Kent, United Kingdom
Dumfries and Galloway Royal Infirmary
🇬🇧Dumfries, United Kingdom
Princess Anne Hospital
🇬🇧Hants, United Kingdom
Claredon Wing, Leeds General Infirmary
🇬🇧Leeds, United Kingdom
St James' University Hospital
🇬🇧Leeds, United Kingdom
Queen's Medical Centre Nottingham University Hospital
🇬🇧Nottingham, United Kingdom
James Cook University Hospital
🇬🇧Middlesborough, United Kingdom
Sheffield Children's Hospital
🇬🇧Sheffield, United Kingdom
Royal Hampshire County Hospital
🇬🇧Winchester, United Kingdom
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hospital Severo Ochoa
🇪🇸Madrid, Spain
University Hospital State University of New York at Stony Brook Department of Pediatrics
🇺🇸Stony Brook, New York, United States
Children's Hospital Medical Center Of Akron
🇺🇸Akron, Ohio, United States
West Virginia University
🇺🇸Morgantown, West Virginia, United States
The Medical College Of Georgia
🇺🇸Augusta, Georgia, United States
The Brooklyn Hospital Center
🇺🇸Brooklyn, New York, United States
Saint Francis Hospital EOPC
🇺🇸Tulsa, Oklahoma, United States
Scott & White Memorial Hospital
🇺🇸Temple, Texas, United States
Shands Hospital At The University Of Florida
🇺🇸Gainesville, Florida, United States
Bronx-Lebanon Hospital Center
🇺🇸Bronx, New York, United States
Jacobi Medical Center
🇺🇸Bronx, New York, United States
MUSC
🇺🇸Charleston, South Carolina, United States
Nemours Children's Clinic Biomedical Research
🇺🇸Orlando, Florida, United States
Kapiolani Medical Center for Woman and Children
🇺🇸Honolulu, Hawaii, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Tulane Hospital for Children
🇺🇸New Orleans, Louisiana, United States
Children's Mercy Hospital
🇺🇸Kansas City, Missouri, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States
University of North Carolina-School of Medicine
🇺🇸Chapel Hill, North Carolina, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States