Risk-based Screen and Prognostic Analysis for Second Primary Malignancies in Kidney Cancer Patients: A Retrospective Cohort Study Based on Large-scale Population and Mendelian Randomization Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72,408
- 试验地点
- 1
- 主要终点
- Overall survival (OS)
研究概览
简要总结
Second primary malignancy (SPM) significantly impacts the survival and prognosis of patients. This study endeavors to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct predictive nomograms.
详细描述
In recent years, with the advancement of cancer treatment techniques and the prolonged survival of patients, the prevalence of Second primary malignancy (SPM) has been escalating, emerging as a significant health issue among cancer survivors. The goal of this study is to identify risk and prognostic factors associated with SPM after first primary kidney cancer and construct nomograms to provide clinical evidence. The main questions this study aims to answer are: (1) What are the risk factors associated with the prevalence of SPM after kidney cancer? (2) What are the prognostic factors associated with the overall survival (OS) of kidney cancer patients with SPM? (3) How to accurately predict the probability of developing SPM after kidney cancer and the OS of kidney cancer patients with SPM? In this retrospective population-based cohort study, Patients diagnosed with first primary kidney cancer between 2000 and 2020 were retrospectively enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Researchers will concentrate on the risk and prognostic factors of SPM after kidney cancer, and develop nomograms to forecast the development and overall survival (OS) of SPM after kidney cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) Diagnosed age was between 18 and 80 years old
- •(2) Diagnosed histologically confirmed as first primary kidney cancer
- •(3) The staging of kidney cancer was early or localized advanced (T1/2/3N0M0)
- •(4) Detailed survival data and follow-up information should be provided
排除标准
- •(1) Histological conformation for diagnosis was unavailable
- •(2) The type of reporting source was "Death certificate only" or "Autopsy only"
- •(3) Patients with other malignancies before the diagnosis of primary kidney cancer
- •(4) The staging of kidney cancer was not early or localized advanced (T1/2/3N0M0)
- •(5) Diagnosis interval between first primary malignancy (FPM) and second primary malignancy (SPM) was less than 6 months
- •(6) The information was not complete
结局指标
主要结局
Overall survival (OS)
时间窗: From the date of diagnosis of the second primary malignancy to the date of death from any cause or the data of last follow-up, whichever came first, assessed up to 20 years.
OS was calculated as the time interval from the diagnosis of the second primary malignancy to death or the time to the last follow-up.
Developing a second primary malignancy (SPM)
时间窗: This time was calculated as the time interval from the diagnosis of first primary kidney cancer to the diagnosis of second primary malignancy, assessed up to 20 years.
This time was calculated as the time interval from the diagnosis of first primary kidney cancer to the diagnosis of second primary malignancy.
次要结局
- Cancer-specific survival (CSS)(From date of diagnosis of the second primary malignancy until the date of death from the same disease or the date of last follow-up, whichever came first, assessed up to 20 years.)
研究者
GONG Kan
Chief physician
Peking University First Hospital