Application of ROTEM Technology in Aortic Surgery Under Cardiopulmonary Bypass and Circulatory Arrest
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Petrovsky National Research Centre of Surgery
- Enrollment
- 81
- Locations
- 1
- Primary Endpoint
- Activated coagulation time
Overview
Brief Summary
Comparison of the diagnostic capabilities of rotational thromboelastometry (ROTEM) and standard coagulogram in the detection of disorder and correction of the hemostasis system in the perioperative period in patients who underwent surgical intervention on the aorta under cardiopulmonary bypass and or circulatory arrest.
Detailed Description
The patient is monitored in the intensive care unit according to the following scheme: ROTEM (NATEM, INTEM, EXTEM, FIBTEM; with high clotting time (CT) values in INTEM - HEPTEM is done) and a coagulogram (activated coagulation time (ACT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, antithrombin III, platelet aggregation) are done on admission and after 6 hours - with a smooth course of the perioperative period. If it is necessary or the development of disorders in the form of bleeding or thrombosis that require correction, ROTEM and a coagulogram are done, treatment is carried out, and after elimination of the causes, ROTEM and a coagulogram are examined in dynamics to assess the effectiveness of the therapy.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age from 18 to 80 years.
- •Patients after surgical interventions on the aorta with cardiopulmonary bypass and/or circulatory arrest (operations on the ascending aorta, aortic arch and thoracoabdominal aorta).
Exclusion Criteria
- •Patients with other cardiac surgery, including isolated endovascular interventions on the aorta.
Outcomes
Primary Outcomes
Activated coagulation time
Time Frame: an average of during the first day after surgery
Сhanges of the activated coagulation time
The coagulation index
Time Frame: an average of during the first day after surgery
Сhanges of the coagulation index
Secondary Outcomes
- Percentage of serious infectious complication(an average of 24 hours after surgery)
- Percentage of repeated operations(an average of 24 hours after surgery)
- Percentage of multiple organ failure(an average of 24 hours after surgery)
Investigators
Aleksandr Eremenko
Clinical Professor
Petrovsky National Research Centre of Surgery