Comparative evaluation of Platelet Rich Fibrin (PRF) and Titanium-Platelet Rich Fibrin (T-PRF) in the Treatment of Intrabony defects using 1% Metformin gel - A Clinical Study.

The aim of the present study is to compare the clinical and radiographic success rate of PRF and TPRF  using 1% Metformin gel in Intrabony Defects among chronic Periodontitis patients of 30 to 60 years of age. A total sample of 26 sites will be selected according to the following inclusion and exclusion criteria or selection parameters: INCLUSION CRITERIA: 1.•Apparently healthy individuals.•Presence of Intrabony defect (IBD) depth ≥3 mm and interproximal probing depth (PD) ≥5 mm after phase I therapy.

EXCLUSION CRITERIA: â€¢HISTORY OF: Aggressive Periodontitis. Smoking and tobacco use. Systemic conditions are known to affect the periodontal status. Medications are known to affect the gingival condition. Pregnant or lactating women. Hematological disorders and insufficient platelet count after re-evaluation of Phase I therapy. The selected samples will be randomized into two groups with 13 samples each. Under local anesthesia access Flap will be reflected. Root planing, Debridement, and root biomodification will be done. Blood will be drawn from systemically healthy patients and will be centrifuged in desired RPM. Based on the test and control group; PRF AND T-PRF MIXED WITH 1% METFORMIN GEL will be placed in the defect site respectively. The flap will be approximated and sutured, periodontal dressing will be given. Post-operatively patients will be prescribed appropriate analgesics and antibiotics for 5 days and OHI will be reinforced. Both the groups will be followed up for the assessment of clinical and radiographic parameters at 0,3,6 months intervals. The above-obtained data will be statistically analyzed.