Evaluation of pain in orthodontic patients

Not Applicable

• Conditions: Condition 1: Pain. Condition 2: Interleukin 21. Condition 3: Interleukin 6. Condition 4: Interleukin 17F. Condition 5: Interleukin 17A.

• Registration Number: IRCT20111130008257N2
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Good general and periodontal health
Good oral hygiene
Orthodontic treatment plan must not include tooth extraction
Age: 12-25 years old
Crowding in the anterior mandibular segment.

Exclusion Criteria

Chronic NSAID intake
Presence of block outed tooth that does not allow the bracket to be placed in the initial bonding session
Pregnancy
Use of anti-inflammatory drugs in the month before the study
Antibiotic therapy in the past 6 months
Any previous orthodontic treatment
Radiographic evidence of periodontal bone loss
Spacing between the teeth in anterior segment of mandible

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: Pain assessment will be done before wire insertion,1 hour,12 hours,24 hours,48 hours,7 days and 14 days after wire insertion. Method of measurement: questionnaire.;Interleukin 21. Timepoint: Interleukin 21 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 6. Timepoint: Interleukin 6 will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17F. Timepoint: Interleukin 17F will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.;Interleukin 17A. Timepoint: Interleukin 17A will be measured before wire insertion,1 hour,24 hours and 48 hours after wire insertion. Method of measurement: BEAD BASED KITS.