Can 10 Seconds Inspiratory Hold Open Atelectasis in Mechanically Ventilated Patients?

Not Applicable

• Conditions: Atelectasis
• Interventions: Other: Inspiratory hold

• Registration Number: NCT02285894
• Lead Sponsor: Oslo University Hospital

Brief Summary

This study evaluates whether sustaining inspiratory pressure for 10 seconds at a time can open collapsed lung areas in non-dependant regions of the lung in mechanically ventilated patients.

Detailed Description

Collapse of lung volume, atelectasis, is a common complication in sedated and mechanically ventilated patients. In adults the atelectasis occur mainly in the dependant areas of the lung. In this study the investigators examine whether these atelectasis can be opened by repeatedly sustaining the inspiratory pressure for 10 seconds when the patient has been positioned so that the atelectasis is located in a non-dependant position. Furthermore, the investigators examine how many times the inspiratory pressure needs to be sustained before the atelectasis is opened and at what pressure.

Study Timeline

• Status Verified: 2014-11
• Study Start: 2014-11
• Study First Submitted: 2014-11-05
• Study First Submitted QC: 2014-11-06
• Study First Posted: 2014-11-07
• Last Update Submitted: 2014-11-21
• Last Update Posted: 2014-11-24
• Primary Completion: 2015-04
• Study Completion: 2015-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Continuously or intermittently mechanically ventilated with artificial airway (endotracheal tube or tracheostomy tube)
• Pressure controlled or pressure supported ventilator mode
• PEEP ≤ 12 cm H2O, registered peak pressure ≤ 32 cm H2O
• Non-ventilated lung regions according to E.I.T. measurements
• Richmond Agitation Score 0 -(-5)
• Circulatory stable or stabilized

Exclusion Criteria

• Pregnancy
• BMI > 50
• Pacemaker or other electrically active implants
• Skin lesions, wounds or bandages on chest area where E.I.T. belt needs to be placed
• Undrained pneumothorax
• Pulsating air-mattress
• Unstable skeletal injury to spinal column
• Recent brain injury or spinal chord injury
• Recent injury to heart, to major blood vessels in chest, to major airways or to the oesophagus.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Inspiratory hold	Inspiratory hold	Mechanical inspiratory pressure held for 10 seconds at a time.

Primary Outcome Measures

Name	Time	Method
Ventilation in previously non-ventilated lung tissue	During intervention and for 30 minutes after ended intervention	Registered using electrical impedance tomography, E.I.T., via PulmoVista500 by Dräger Medical

Trial Locations

Locations (1)

Oslo university Hospital, Ullevål; 🇳🇴 Oslo, Norway