Quantitative Analysis of 3T Whole Heart Coronary Magnetic Resonance Angiogram Improves Detection of Functionally Significant Coronary Artery Disease
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 89
- Locations
- 1
- Primary Endpoint
- Presence of functionally significant coronary stenosis
Study Overview
Brief Summary
This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.
Detailed Description
Coronary MR angiography is performed with a 3.0-T imager with 32-channel coils. Qunatitative analysis of coronary MR angiogram is evaluated on the basis of the signal intensity (SI) profile along the vessel. Quantitative analysis of coronary MR angiogram (QCMRA) is calculated as [1 - (SImin/SIref)] x 100, where SImin is minimal SI and SIref is corresponding reference SI. Diagnostic performance of quantitative analysis of coronary MR angiogram for predicting functional significant coronary stenosis was evaluated by using fractional flow reserve (FFR) as the reference standard.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥ 18 years
- •1 or more coronary stenoses in the major coronary artery with a vessel diameter ≥ 2mm on coronary MR angiogram
- •Patient who were planned to undergo invasive coronary angiography and fractional flow reserve
Exclusion Criteria
- •clinically unstable patient
- •a history of coronary revascularization
- •infiltrative cardiomyopathy, hypertropic cardiomyopathy, myocarditis
- •contraindication to use of adenosine
- •complete occlusion of target lesion
Outcomes
Primary Outcomes
Presence of functionally significant coronary stenosis
Time Frame: within 1 month
fractional flow reserve \< 0.8
Secondary Outcomes
No secondary outcomes reported
Investigators
Yeonyee E Yoon, MD
Associate Professor
Seoul National University Bundang Hospital