Clinical Comparative efficacy and safety of Unani Drugs
- Conditions
- Chronic pharyngitis,
- Registration Number
- CTRI/2023/04/051674
- Lead Sponsor
- State Unani Medical College, himmatganj Prayagraj
- Brief Summary
Pharyngitis is defined as mucosal inflammation of the oropharynx, hypopharynx,adenoid and tonsils. It is a type of inflammation caused by an upper respiratory tract infection. It may be classified as acute or chronic. Acute pharyngitis maybe catarrhal, purulent, or ulcerative, depending on the causative agent and the immune capacity of the affected individual. Chronic pharyngitis may be catarrhal, hypertrophicor atrophic. Chronic inflammatory condition of the pharynx pathologically, characterized by hypertrophy of mucosa, seromucinous glands, subepithelial lymphoid follicles, and even the muscular coat of the pharynx . Virus is the most common cause of pharyngitis. About 25% children and 10% of adults are affected by Streptococcal pharyngitis. Uncommon cause are some other bacteria (gonorrhoea), fungus, irritantssmoke, allergens, and gastroesophageal reflux disease. Chronic pharyngitis has many potential underlying causes, and if a sore throat does not clear up even after a course of antibiotics, it is best to seek further medical advice. It often indicates the presence of an underlying problem, and 336.2treatment to relieve it includes treating the underlying cause. To relieve the sore throat itself, people with chronic pharyngitis can gargle with warm saline solutions, stay wellhydrated, avoid smoking and manage pain with over-the-counter medication such as acetaminophen/paracetamol6. But acetaminophene have various side effects like hypersensitivity reactions, nephrotoxicity, anemia and may cause severe adverse effects include anaphylactic reaction . Fortunately our Unani system of medicine provides very effective treatment for Pharyngitis. It is mentioned in classical Unani literature asWaram-i-Halaq. It is described as the inflammation of Ghisha-e-mukhati (mucous membrane) of Halaq (Pharynx)8. There are many single and compound drugs for the management of pharyngitis which are being used for a longer duration without any known side effects for example, Khyar Shambhar (Cassia fistula Linn), Banafsha (Viola odorata Linn), Milk of Fig, Tukhm e Hulba (Trigonella foenum)etc9. So there is need to develop alternative herbal medicines to cure the Waram-i-Halaq. By keeping this background in the mind this study is being drawn after very comprehensive and thorough review of classical Unani literature regarding sign & symptoms, clinical examination, medical management.
keeping the above facts in view, it has been planned to conduct a clinical trial entitled “A comparative study of Sharbat Toot Siyah with Laooq Sapistan in the management of Waram-i-Halaq Muzmin(Chronic Pharyngitis)â€-A randomized Trial
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 60
1 Patients of either sex in the age group of 18-60 years 2 Patient with clinically diagnosed with Waram-i-halaq (Chronic Pharyngitis) 3 Patient with raised Absolute eosinophil count and Complete blood count.
- Age below 18 and above 60years.
- 1 Pregnancy and lactation.
- 2 Those have history of systematic and metabolic disease.
- 3 Those diagnosed with any other disease of the nose and throat.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy will be assessed clinically by improvement in clinical features and following parameter. 0, 7, 14, 21, 28, | 35, 42 days 2. Reduction in Visual Analogue Scale (VAS) 0, 7, 14, 21, 28, | 35, 42 days 1. Improvement of subjective parameters. 0, 7, 14, 21, 28, | 35, 42 days 3. Reduction in Absolute Eosinophil count and CBC 0, 7, 14, 21, 28, | 35, 42 days
- Secondary Outcome Measures
Name Time Method Improvement in Clinical Sign and Symptoms 0 and 6th week
Trial Locations
- Locations (1)
OPD/IPD of Ain, Uzn, Anf, Halaq wa Asnan n State Unani Medical
🇮🇳Allahabad, UTTAR PRADESH, India
OPD/IPD of Ain, Uzn, Anf, Halaq wa Asnan n State Unani Medical🇮🇳Allahabad, UTTAR PRADESH, IndiaMd MokarramPrincipal investigator9997663773mdmokarram178@gmail.com