Frequency and Risk Factors of Acute Myeloid Leukemia

Not yet recruiting

• Conditions: Myeloid Leukemia

• Registration Number: NCT05787951
• Lead Sponsor: Assiut University

Brief Summary

1. to assess the frequency of acute myeloid leukemia at clinical Haematology unit of Assiute university hospital

2. to study correlations of known risk factors and if there are new risk factors participate in increasing frequency of acute myeloid leukemia

Detailed Description

Acute myeloid leukaemia (AML) is a rare heterogeneous disease comprising a group of hematopoietic neoplasms originating from the excessive clonal proliferation of myeloid pre- cursor cells \[1\]. Diagnosis of AML is based on morphological diagnosis with proliferation of blast cells ≥ 20% of bone marrow cells, flow cytometric analysis and cytogenetic abnormalities, including the t(8;21)(q22;q22), t(15;17) (q22;q12) and inv (16)(p13.1;q22) which are associated with longer remission and survival, while alterations of chromosomes 5, 7, complex karyotype and 11q23 are associated with poor response to therapy and shorter overall survival \[2\] The etiological agent and pathogenesis of AML are not entirely clear, only few AML cases can be accurately classified through traditional cellular morphological classification \[3\]It is the most common acute leukaemia in adults. It accounts for 1.3% of new cancer patients in the United States, in 2018\[ 4\] Some factors are well documented to increase the risk of some types of leukemia such as benzene exposure and ionizing radiation \[5\] increased frequency of acute myeloid leukemia has been noticed at Haematology unit so the aim of the study to assess the the frequency of acute myeloid leukemia and to evaluate the risk factors for it .

Study Timeline

• Status Verified: 2023-03
• Study First Submitted: 2023-03-15
• Study First Submitted QC: 2023-03-15
• Last Update Submitted: 2023-03-15
• Study First Posted: 2023-03-28
• Last Update Posted: 2023-03-28
• Study Start: 2023-05-01
• Primary Completion: 2025-05-01
• Study Completion: 2025-08-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Adult Patients(above 18 years) diagnosed as acute myeloid leukemia according to WHO diagnostic criteria

Exclusion Criteria

• Patients with other types of leukemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital	Two years

Secondary Outcome Measures

Name	Time	Method
Risk factors of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital	Two years