Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ST Elevation Myocardial Infarction
- Sponsor
- University Hospital, Caen
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Measurement of fibrosis
- Status
- Suspended
- Last Updated
- 4 years ago
Overview
Brief Summary
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
Investigators
Eligibility Criteria
Inclusion Criteria
- •First ST Elevation Myocardial Infarction
- •Primary Percutaneous Coronary Intervention (TIMI 3)
- •Single vessel coronary artery disease
- •Age over 18 years
- •Informed Consent dated and signed
- •Written and spoken French
- •Beneficiary of social security insurance
Exclusion Criteria
- •No Primary Percutaneous Coronary Intervention
- •TIMI 0-2 after Primary Percutaneous Coronary Intervention
- •Significant two or three-vessel coronary artery disease (\> 70% stenosis in at least one of the other two coronary arteries)
- •Past history of myocardial infarction before STEMI
- •Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
- •Pregnant and / or lactating
- •Age under 18 years or guardianship
Outcomes
Primary Outcomes
Measurement of fibrosis
Time Frame: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Measurement of coronary endothelial function
Time Frame: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Secondary Outcomes
- Correlating biomarkers with local and global parameters of coronary endothelial function , inflammation and myocardial fibrosis with early echocardiographic parameters of left ventricular remodeling and cardiac magnetic resonance imaging(3 months)