Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- University Hospital, Caen
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Measurement of fibrosis
Study Overview
Brief Summary
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •First ST Elevation Myocardial Infarction
- •Primary Percutaneous Coronary Intervention (TIMI 3)
- •Single vessel coronary artery disease
- •Age over 18 years
- •Informed Consent dated and signed
- •Written and spoken French
- •Beneficiary of social security insurance
Exclusion Criteria
- •No Primary Percutaneous Coronary Intervention
- •TIMI 0-2 after Primary Percutaneous Coronary Intervention
- •Significant two or three-vessel coronary artery disease (> 70% stenosis in at least one of the other two coronary arteries)
- •Past history of myocardial infarction before STEMI
- •Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
- •Pregnant and / or lactating
- •Age under 18 years or guardianship
Arms & Interventions
STEMI
All patients included in this study (1 arm)
Intervention: (15)-O water positron emission tomography and Biomarkers (Other)
Outcomes
Primary Outcomes
Measurement of fibrosis
Time Frame: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Measurement of coronary endothelial function
Time Frame: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Secondary Outcomes
- Correlating biomarkers with local and global parameters of coronary endothelial function , inflammation and myocardial fibrosis with early echocardiographic parameters of left ventricular remodeling and cardiac magnetic resonance imaging(3 months)