Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- The Change in the Mean Arterial Blood Pressure in Response to an Infusion of Angiotensin II
研究概览
简要总结
Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity.
Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.
详细描述
Vitamin D deficiency and obesity are international epidemics that have both been associated with increased activity of the renin-angiotensin system (RAS). Because increased RAS activity is associated with cardiovascular disease, interventions to lower RAS will have favorable public health impacts.
This study aims to evaluate whether the supplementation of Vitamin D in obese subjects will lower local tissue RAS activity. RAS activity will be evaluated by cross-sectional measurement of RAS components and by quantifying the vascular response to an infusion of angiotensin II. Subjects will be studied while Vitamin D deficient, and will return for repeat study following Vitamin D supplementation, for comparison.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age < 65,
- •Cr < 1.6,
- •25-hydroxyvitamin D < 25 ng/mL,
- •BMI > 30 kg/m2,
- •stage I hypertension.
排除标准
- •diabetes,
- •coronary heart disease,
- •heart failure,
- •renal failure,
- •liver failure,
- •hyperparathyroidism,
- •granulomatous disease.
结局指标
主要结局
The Change in the Mean Arterial Blood Pressure in Response to an Infusion of Angiotensin II
时间窗: baseline and 1 month following vitamin D3 therapy
次要结局
- The Change in Renal Blood Flow in Response to an Infusion of Angiotensin II(baseline and 1 month following vitamin D3 therapy)
研究者
Jonathan S. Williams, MD, MMSc
Assistant Professor of Medicine
Brigham and Women's Hospital