CanTalk : A trial into the benefits of a talking therapy called cognitive behaviour therapy for the treatment of depression in adults with advanced cancer to see whether the intervention is better than treatment as usual

Not Applicable

Completed

• Conditions: Cancer and major depression; Cancer

• Registration Number: ISRCTN07622709
• Lead Sponsor: niversity College London (UK)

Brief Summary

2016 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/26926910 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31097078 (added 20/05/2019) 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31566164 (added 01/10/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-20
• Study Completion: 2016-08-31
• Last Update Posted: 29 October 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

1. A diagnosis of cancer not amenable to curative treatment (this includes patients initially diagnosed with metastatic disease, those at first or subsequent incurable recurrence and who may be receiving palliative treatments including non-curative radiotherapy, chemotherapy, biological therapy or surgery) verified by contacting general practitioners (GPs) or oncologist.
2. A clinical diagnosis of depression through clinical interview on the Mini-International Neuropsychiatric Interview (MINI) (Sheenan et al, 1998)
3. Agreement to be randomised
4. Sufficient understanding of English to be able to engage in CBT
5. The patient is eligible for Improving Access to Psychological Therapies (IAPT) - either they or their GP is in an appropriate catchment area
6. Agreement for GP to be involved so that referral to IAPT can take place through GP

Exclusion Criteria

1. Clinician estimated survival of less than 4 months (verified by contacting patients' oncologists/GP)
2. Suicidal intent; scoring 3 on question 9 of the Beck Depression Inventory (BDI)-II
3. Currently receiving or having received a psychological intervention recommended by Niational Institute for Health and Clinical Excellence (NICE) aimed at treating depression (e.g. Interpersonal Psychotherapy, CBT etc) in the last 2 months
4. Suspected alcohol dependence using the Alcohol Use disorders Identification Test (AUDIT; Saunders et al, 1993)

Study & Design

• Study Type: Interventional
• Study Design: Not specified