Hemodynamic Evaluation and Fluid Response Observation Through Respiratory Maneuvers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Change in heart rate during respiratory manoeuvres
研究概览
简要总结
This study evaluates whether respiratory maneuvers can induce measurable hemodynamic changes and whether these changes may be used to assess fluid responsiveness in healthy volunteers. Hemodynamic parameters are continuously monitored non-invasively during four respiratory maneuvers, passive leg raising, and a fluid challenge. The hemodynamic responses to individual respiratory maneuvers are compared with the response to fluid administration.
详细描述
Fluid responsiveness is commonly assessed using dynamic tests that transiently modify cardiac preload. In spontaneously breathing patients, however, assessment of fluid responsiveness remains challenging because many established dynamic indices rely on controlled mechanical ventilation. This proof-of-concept physiological study investigates whether respiratory maneuvers performed during spontaneous breathing induce measurable hemodynamic changes that could potentially be used for the assessment of fluid responsiveness. Healthy volunteers undergo four respiratory maneuvers: maximal inspiration followed by breath-hold, maximal expiration followed by breath-hold, Valsalva maneuver, and Müller maneuver. Hemodynamic variables are continuously monitored non-invasively. The hemodynamic responses to the respiratory maneuvers are evaluated in relation to passive leg raising and a subsequent fluid challenge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers able to understand and perform the study procedures
排除标准
- •Age <18 years
- •History of cardiac arrhythmia, coronary artery disease, or valvular heart disease
- •Bronchial asthma or other respiratory disease associated with reduced vital capacity
- •History of increased intraocular pressure, including glaucoma, retinopathy, or intraocular implants
- •Inability to cooperate with the study procedures
研究组 & 干预措施
Respiratory Maneuvers and Fluid Responsiveness Assessment
Healthy volunteers undergo a hemodynamic assessment protocol consisting of four respiratory maneuvers, passive leg raising, and a fluid challenge, with continuous non-invasive hemodynamic monitoring.
干预措施: Respiratory Maneuvers and Fluid Responsiveness Assessment Protocol (Procedure)
结局指标
主要结局
Change in heart rate during respiratory manoeuvres
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in heart rate (HR), measured in beats per minute (bpm), during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in systolic arterial pressure during respiratory manoeuvres
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in systolic arterial pressure (SAP), measured in mmHg, during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in mean arterial pressure during respiratory maneuvers
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in mean arterial pressure (MAP), measured in mmHg, during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in pulse pressure variation during respiratory manoeuvres
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in pulse pressure variation (PPV), measured as a percentage (%), during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in cardiac index during respiratory manoeuvres
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in cardiac index (CI), measured in L/min/m², during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in stroke volume index during respiratory maneuvers
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in stroke volume index (SVI), measured in mL/m², during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in systemic vascular resistance index during respiratory maneuvers
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in systemic vascular resistance index (SVRI), measured in dyn·s·cm-⁵·m², during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
Change in stroke volume variation during respiratory manoeuvres
时间窗: During each 20-second respiratory maneuver, within a single study visit.
Change in stroke volume variation (SVV), measured as a percentage (%), during each of four respiratory maneuvers using continuous non-invasive hemodynamic monitoring.
次要结局
未报告次要终点