IRCT20091114002709N54尚未招募3 期
The effect of Ellagic acid on depression, inflammatory index (IFN-?), oxidative (Nrf2) and nitrosative (NO) stress index, Brain Derived Neurotrophic Factor (BDNF), cortisol, serotonin and gene expression of indoleamine dioxygenase enzyme in patients with multiple sclerosis
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 55 years（—）
- 性别
- All
入选标准
- •Willingness to cooperate
- •Age range 18 to 55 years
- •Depression according to Beck's questionnaire (score above 10)
- •No change in the dose of antidepressant medication in the last three months
- •Diagnosis of MS by a neurologist
- •Patients are at recurrence and recovery
- •EDSS <5.5
排除标准
- •Take nutritional, antioxidant, and ellagic acid supplements for a month before the study (except for routine supplements, which are part of the treatment plan for all patients, such as vitamin D)
- •Pregnancy and lactation
- •History of diabetes and other chronic diseases
- •History of other autoimmune diseases
- •Occurrence of recurrence of the disease during study
- •Taking corticosteroids, estrogens, progesterone, immunosuppressants, diuretics during last month
- •Dose changes and the type of medication used during study
- •Change in physical activity
- •Acceptance rate of less than 90% of supplementation
- •Lack of willingness to cooperate
研究者
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