NCT01721187
Completed
Not Applicable
Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety
Duke-NUS Graduate Medical School1 site in 1 country60 target enrollmentOctober 2012
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fasting
- Sponsor
- Duke-NUS Graduate Medical School
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- fMRI - Willingness to Pay task (BDM auction)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.
Investigators
MChee
Professor
Duke-NUS Graduate Medical School
Eligibility Criteria
Inclusion Criteria
- •Chinese ethnicity
- •21 to 45 years old
- •English as first language
- •Right-handed
- •Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
- •Weigh less than 100kg with an abdominal circumference of less than 120cm
- •Non-smoker, or only smoke occasionally (less than 5 sticks a week)
- •Consume less than 2 units (200 mg) of caffeine a day
- •Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
- •Habitually sleep before 1am and wake before 9am
Exclusion Criteria
- •On a restrictive diet (e.g., vegetarian/vegan diet)
- •History of food allergies
- •History of psychiatric or neurological disorders
- •History of chronic medical illness
- •Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
- •Shift worker
- •Claustrophobic
- •High astigmatism (high = \>2.00 diopters)
- •Colour-blind
Outcomes
Primary Outcomes
fMRI - Willingness to Pay task (BDM auction)
Time Frame: Fed and fasted visits (Wks 1 & 2)
A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.
fMRI - Monetary and Food Incentive Delay task
Time Frame: Fed and fasted visits (Wks 1 & 2)
A measurement of neural response to anticipating and receiving money and food rewards.
Study Sites (1)
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