NL-OMON33978尚未招募不适用
The airway smooth muscle cell in asthma: A genomics approach - Genomics in asthma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 48
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Asthmatic patients :
- •- Age between 18 * 50 years
- •- History of episodic chest tightness and wheezing
- •- Intermittent or mild persistent asthma according to the criteria by the Global Initiative for Asthma
- •- Non-smoking or stopped smoking more than 12 months ago and 5 pack years or less
- •- Clinically stable, no exacerbations within the last 6 weeks prior to the study. Occasional usage of inhaled short-acting Beta2-agonists as rescue medication is allowed, prior and during the study.
- •- Steroid-naïve or those patients who are currently not on corticosteroids and have not taken any corticosteroids by any dosing-routes within 8 weeks prior to the study
- •- Baseline FEV1 >70% of predicted
- •- Airway hyperresponsiveness, indicated by a positive methacholine challenge with PC20 <8mg/ml
- •- Positive skin prick test (SPT) to one or more of the 12 common aeroallergen extracts, defined as a wheal >3mm in diameter;Healthy, non-asthmatic patients are recruited using the following inclusion criteria:
- •- Age between 18 * 50 years
- •- Non-smoking or stopped smoking more than 12 months and 5 pack years or less
- •- Baseline FEV1 >70% of predicted
- •- Negative methacholine challenge or PC20 >8mg/ml
- •- No usage of steroids by any dosing route
- •Additionally, non-asthmatic non-allergic patients must have a negative skin prick test (SPT) to one of the 12 common aeroallergen extracts, whereas non-asthmatic allergic patients must have a positive SPT.;Regarding confirming the feasibility of RNA-analysis:
- •- Chronic cough patients who are scheduled to undergo a routine, diagnostic bronchoscopy with biopsy collection.
排除标准
- •- History of clinical significant hypotensive episodes or symptoms of fainting, dizziness, or light-headedness
- •- Women who are pregnant or lactating or who have a positive urine pregnancy test at screening
- •- Chronic use of any other medication for treatment of lung disease other than short-acting Beta2-agonists
- •- Ongoing use of tobacco products of any kind or previous usage with a total pack year of 6 or greater
研究者
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