ISRCTN15983654进行中（未招募）Unknown
PROton beam Therapy versus Intensity-modulated radiotherapy for Sinonasal cancer
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 入组人数
- 276
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Written and informed consent obtained from participants
- •2. Agreement of participant to comply with the requirements of the trial, including travel and residential stay at the proton centre if allocated to PBT
- •3. Histologically confirmed:
- •3.1. Sinonasal squamous cell carcinoma (SNSCC) or
- •3.2. Sinonasal adenocarcinoma (SNAC)
- •4. Primary tumour (T) staging (AJCC 8th edition):
- •4.1. T3-4 all subsites (maxillary, ethmoid, sphenoid or frontal sinuses, and/or nasal cavity) or
- •4.2. T2 nasal cavity involving ethmoid sinus
- •5. Age > = 16 years old
- •6. WHO performance status 0-1
- •7. Multidisciplinary team (MDT) decision for curative intent treatment
- •7.1. with surgery or
- •7.2. without
排除标准
- •1. Distant metastatic disease, as determined by routine pre-operative radiological staging investigations
- •2. Previous head and neck radiotherapy
- •3. Any invasive malignancy within the previous 2 years (other than non-melanomatous skin carcinoma or cervical carcinoma in situ)
- •4. Previous or concurrent illness that would interfere with completion of therapy, trial assessments or follow-up (in the opinion of PI)
- •5. Pregnant or breastfeeding women
- •6. Participants unwilling or unable to use adequate non-hormonal contraception
研究者
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