A clinical trial to compare the effectiveness of two drugs (sugammadex vs neostigmine-glycopyrolate)in patient undergoing cardiac surgeries.
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/08/072509
- Lead Sponsor
- Vignesh D
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Elective CABG or AVR surgeries or both .
ASA grade 1,2,3,4 .
Ejection fraction of more than or equal to 45%.
Exclusion Criteria
Participant refusal.
Emergency cases.
Ejection fraction of less than 45%,moderate or severe RV failure .
CKD with moderate to severe reduced GFR (less than 30ml/min/1.73m2).
Participant with neuromuscular disorders.
History of adverse reaction to study drug.
Chronic opioid use.
BMI of more than 35kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy and safety of sugammadex vs neostigmine-glycopyrolate in reversal of neuromuscular blockade following cardiac surgeries.Timepoint: TOF will be measured just before drug administration, at the time of extubation and at interval of 3,5,10 minutes after extubation.
- Secondary Outcome Measures
Name Time Method To compare the hemodynamic parameters such as Heart rate,systolic blood pressure,diastolic blood pressure,SpO2 between sugammadex & neostigmine glycopyrolate group.Timepoint: At the time of extubation,3 min,5 min & 10 min after extubation.