Efficacy and safety during Endoscopic Retrograde Cholangio-Pancreatography under Total Intravenous Anesthesia-Propofol alone versus Propofol supplemented with Dexketa, a comparative study in Medical College Kolkata

Endoscopic Retrograde Cholangio Pancreatography (ERCP) is an invasive procedure and hence is distressing for awake patients, requiring adequate level of anaesthesia. Recent advancements have encouraged use of monitored anaesthesia care (MAC) , that allows the patient to tolerate unpleasant procedures while maintaining cardio-respiratory function. The main aim was to compare the effect of Propofol alone and Propofol with Ketamine and Dexmedetomidine on the hemodynamics during ERCP, recovery profile and side effects (if any).

This is a comparative study. Adult patients from age group of 18-70 years belonging to ASA-I and ASA-II who will undergo ERCP under TIVA (Total Intravenous Anaesthesia) will be taken and will randomly be assigned to either of the two groups. Both groups will receive 0.2mg Glycopyrrolate, 4mg Ondansetron, 1mg Midazolam, 50mcg Fentanyl and 40mg Hyoscine. Group A patients will receive 30mg Propofol as bolus dose and will be repeated according to requirements. Group B patients will receive 0.5mcg/kg Dexmedetomidine as loading dose and 0.3mcg/kg as infusion dose. 20mg Propofol will be given before negotiating scope and then 1ml (1:1) mixture of Propofol and Ketamine will be repeated every 10 minutes. Total Propofol consumption, hemodynamics, quality of recovery and side effects (if any) will be recorded at regular intervals.