Study Evaluating Premarin and Bazedoxifene Potential Interaction
- Registration Number
- NCT00745173
- Lead Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
- Brief Summary
The purpose of this study is to evaluate the pharmacokinetics (absorption, distribution, breakdown and elimination in the body) of a single dose of bazedoxifene (BZA) 20 mg tablet when administered together with multiple doses of Premarin (conjugated estrogens or CE) to healthy postmenopausal women.
Information will also be obtained regarding the safety and tolerability of this combination in healthy, postmenopausal women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- For inclusion into the study, women must be healthy and postmenopausal (either naturally or surgically) between the ages of 35 and 70, inclusive.
- Blood hormone levels must be consistent with a postmenopausal state (for specified subjects).
- They can either be a non-smoker or smoke less than 10 cigarettes per day, and be able to abstain from smoking during clinic confinements
Exclusion Criteria
- A subject will be excluded from participation if they :
- Have participated in a clinical drug study within 30 days prior to study medication administration;
- Have a history of drug or alcohol abuse within 1 year or consume more than 2 standard units per day of alcohol (a standard unit equals 12 ounces of beer, 1 ½ ounces of 80-proof alcohol or 6 ounces of wine);
- Donate any other plasma or blood during the total study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 1 Premarin -
- Primary Outcome Measures
Name Time Method Pharmacokinetic (absorption, distribution, breakdown and elimination in the body) parameters 3 months
- Secondary Outcome Measures
Name Time Method To continue assessment of the safety profile as well as the tolerability the two drugs administered in combination in this population. 3 months
Trial Locations
- Locations (1)
Dr. David Carter
🇺🇸Austin, Texas, United States