State Dependence of Prefrontal Transcranial Magnetic Stimulation

Phase 4

Recruiting

• Conditions: Healthy
• Interventions: Device: Brain state while receiving TMS

• Registration Number: NCT05962385
• Lead Sponsor: University of Minnesota

Brief Summary

The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-07-12
• Study First Submitted QC: 2023-07-24
• Study First Posted: 2023-07-27
• Study Start: 2023-08-24
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-07
• Last Update Posted: 2025-04-09
• Primary Completion: 2025-08-01
• Study Completion: 2025-08-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Age 18 - 65,
• healthy controls

Exclusion Criteria

• Diagnosed psychiatric disorder
• Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording)
• Potential contraindication to TMS (as identified by the TMS safety screener)
• Any previous adverse reaction to TMS or MRI
• Diagnosed epilepsy or previously experienced a seizure
• Diagnosed neurological condition, such as stroke or tinnitus
• Experienced a head trauma that was diagnosed as concussion
• Current use of, or recent withdrawal from, medications that can increase the risk of seizure
• Currently pregnant
• Any metal in the head (excluding mouth)
• Any implanted medical device

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Healthy control	Brain state while receiving TMS	All participants receive the same procedures

Primary Outcome Measures

Name	Time	Method
Theta-gamma cross frequency coupling	0-500 ms after each TMS stimulus	A metric of brain function measured with EEG - the coupling of theta oscillation phase with gamma power. This will be measured immediately following the intervention (TMS stimulation).
Cortical excitability	60-300 ms after each TMS stimulus	TMS-evoked potentials will be measured with EEG to examine cortical excitability after TMS. This will be measured immediately following the intervention (TMS stimulation).

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States