Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
- Conditions
- Transient Ischemic AttackStroke
- Interventions
- Registration Number
- NCT04078737
- Lead Sponsor
- Beijing Tiantan Hospital
- Brief Summary
The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
- Detailed Description
According to the Global Burden of Disease(GBD) Study 2016, China bears the greatest lifetime risk of stroke from 25-year-age onward. Minor ischemic events, including minor stroke and TIA, were major parts of stroke manifestations. Events (CHANCE) has shown that 21-day dual antiplatelet therapy (clopidogrel and aspirin) compared to aspirin alone which initiated within 24 hours after symptoms onset would reduce 32% risk of stroke recurrence within 90 day, but not in carriers of CYP2C19 loss-of-function (LOF) alleles. The primary purpose of this study is to compare ticagrelor plus aspirin with clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
Both intent analysis (ITT) and compliance program set (PPS) were used for analysis.
We will use Kaplan-Meier estimates of the cumulative risk of stroke (ischemic or hemorrhagic) event during maximum 90-day follow-up, with hazards ratios and 95% CI calculated using Cox proportional hazards methods and the log-rank test to evaluate the treatment effect. All statistics will be 2-sided with P\<0.05 considered significant, accounting for interim analyses.
All patients who received study drugs and with at least one safety follow-up record will be included in the safety population. The data for safety evaluation included adverse reactions observed during the trial and changes in laboratory data before and after treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6412
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ticagrelor plus Aspirin Group Ticagrelor and Aspirin Ticagrelor of loading dosing of 180mg followed by 90mg bid for 3 months plus aspirin of loading dose of 75-300mg followed by 75mg daily for 21 days Clopidogrel plus Aspirin Group Clopidogrel and Aspirin Clopidogrel of loading dosing of 300mg followed by 75mg daily for 3 months plus aspirin loading dose of 75-300mg followed by 75mg daily for 21 days
- Primary Outcome Measures
Name Time Method Any new stroke events (ischemic stroke or hemorrhagic stroke) within 3 months 3 months after randomization The aim is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
- Secondary Outcome Measures
Name Time Method Any new stroke events within 30 days and 1 year 30 days and 1 year after randomization Percentage of patients with the 30 days and 1 year new stroke events (ischemic stroke/ hemorrhagic stroke) as a cluster and evaluated individually.
New clinical vascular events including stroke, TIA, myocardial infarction, and vascular deaths within 3 months and 1 year 3 months and 1 year after randomization Percentage of patients with the 3 months and 1 year new clinical vascular events (ischemic stroke/ hemorrhagic stroke/ TIA/ myocardial infarction/vascular death)
New ischemic stroke within 3 months and 1 year 3 months and 1 year after randomization Percentage of patients with the 3 months and 1 year new ischemic stroke will be evaluated.
Incidence and severity of recurrent stroke and TIA during follow-up to 3 months and 1-year 3 months and 1 year after randomization (Severity is measured using a six-level ordered categorical scale that incorporates the mRS: fatal stroke/severe non-fatal stroke \[mRS 4 or 5\]/moderate stroke \[mRS 2 or 3\]/mild stroke \[mRS 0 or 1\]/TIA/no stroke-TIA).
Disabling stroke (Modified Rankin Scale score, mRS>1) at 3 months and 1 year 3 months and 1 year after randomization Modified Rankin Scale, a commonly used scale for measuring the degree of dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. 0 - No symptoms.1 - No significant disability. Able to carry out all usual activities, despite some symptoms.2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.3 - Moderate disability. Requires some help, but able to walk unassisted.4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.6 - Dead. The mRS scores between 3 to 6 points are considered to be poor functional outcome. (dead).
Neurological impairment at 3 months (NIHSS increased≥4 from baseline) 3 months after randomization The National Institutes of Health Stroke Scale (NIHSS) score classifies neurologic deficit from 0 (no deficit) to 42 (most severe).
Quality of Life (EuroQol EQ-5D scale) at 3 months and at 1 year 3 months and 1 year after randomization Further efficacy exploratory analysis:Quality of Life (EuroQol EQ-5D scale). We will use the EQ-5D-5L scale to evaluate the quality of life. EQ-5D-5L is a standardized instrument for measuring generic health status. It has been widely used in population health surveys, clinical studies, economic evaluation and in routine outcome measurement in the delivery of operational healthcare. The EQ-5D-5L has five domain scales (mobility, self-care, usual activities, pain and discomfort, and anxiety and depression) and five levels for each domain.
Stratified analysis 3 months and 1 year after randomization The influence on treatment effect of age, gender, Body Mass Index (BMI), index event type (TIA vs. minor stroke), time from index event to randomization, etiology subtype, diabetes mellitus, hypertension, type of LOF allele, previous ischemic stroke or TIA, prior antiplatelet therapy, prior statin therapy, prior smoking status, and symptomatic intracranial and extracranial artery stenosis will be evaluated in subgroup analyses.
Trial Locations
- Locations (214)
Guiyang Second People's Hospital
🇨🇳Guiyang, Guizhou, China
The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine
🇨🇳Fuzhou, Fujian, China
Sanming First Hospital Affiliated to Fujian Medical University
🇨🇳Sanming, Fujian, China
Wuwei People's Hospital
🇨🇳Wuwei, Gansu, China
Dongguan People's Hospital
🇨🇳Dongguan, Guangdong, China
Hainan West Central Hospital
🇨🇳Danzhou, Hainan, China
The First Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Affiliated Hospital of Hebei University
🇨🇳Baoding, Hebei, China
HaLixun InternationalPeace Hospital
🇨🇳Hengshui, Hebei, China
Hengshui fourth People Hospital（Department of Neurology ward 2）
🇨🇳Hengshui, Hebei, China
The Fourth People's Hospital of Hengshui City（Department of Neurology ward 1）
🇨🇳Hengshui, Hebei, China
Second Central Hospital of Baoding
🇨🇳Zhuozhou, Hebei, China
The Second Hospital of Harbin Medical University（Department of Neurology ward ）
🇨🇳Harbin, Heilongjiang, China
Daqing Oilfield Gengeal Hospital
🇨🇳Daqing, Heilongjiang, China
Daqing People's Hospital
🇨🇳Daqing, Heilongjiang, China
The Second Hospital of Harbin Medical University（Department of Neurology ward 1）
🇨🇳Harbin, Heilongjiang, China
The First Affiliated Hospital of Jiamusi University
🇨🇳Jiamusi, Heilongjiang, China
Anyang People's Hospital
🇨🇳Anyang, Henan, China
Sanmenxia Central Hospital
🇨🇳Sanmenxia, Henan, China
Suixian county Hospital of Traditional Chinese Medicine
🇨🇳Shangqiu, Henan, China
Qiqihar Rongjian Institute of Stroke Prevention and Treatment
🇨🇳Qiqihar, Heilongjiang, China
Xiuwu County People's Hospital
🇨🇳Jiaozuo, Henan, China
Luohe Central Hospital
🇨🇳Luohe, Henan, China
The first Affiliated Hospital of Henan University of Science and Technology
🇨🇳Luoyang, Henan, China
Zhumadian Hospital of Traditional Chinese Medicine
🇨🇳Zhumadian, Henan, China
First hospital of Changsha city
🇨🇳Changsha, Hunan, China
The Second Affiliated Hospital of Henan University of Science and Technology
🇨🇳Luoyang, Henan, China
Xingyang People's Hospital
🇨🇳Xingyang, Henan, China
The first Affiliated Hospital of Xinxiang Medical University
🇨🇳Xinxiang, Henan, China
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
🇨🇳Zhengzhou, Henan, China
Gongyi People's Hospital
🇨🇳Zhengzhou, Henan, China
Zhoukou Yongshan Hospital
🇨🇳Zhoukou, Henan, China
Fourth People's Hospital of Chenzhou
🇨🇳Chenzhou, Hunan, China
Yueyang Second People's Hospital
🇨🇳Yueyang, Hunan, China
Shangrao City People's Hospital
🇨🇳Shangrao, Jiang XI, China
Jiangsu Provincial Hospital of Traditional Chinese Medicine
🇨🇳Nanjing, Jiangsu, China
Hai 'an People's Hospital
🇨🇳Nantong, Jiangsu, China
Siyang Kangda Hospital
🇨🇳Suqian, Jiangsu, China
Xinghua People's Hospital
🇨🇳Taizhou, Jiangsu, China
Wuxi People's Hospital
🇨🇳Wuxi, Jiangsu, China
Affiliated Hospital of Jiangnan University
🇨🇳Wuxi, Jiangsu, China
xuzhou Central Hospital
🇨🇳Xuzhou, Jiangsu, China
Xuzhou coal mining group General Hospital
🇨🇳Xuzhou, Jiangsu, China
Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 2）
🇨🇳Xuzhou, Jiangsu, China
Subei People's Hospital of Jiangsu province
🇨🇳Yangzhou, Jiangsu, China
Affiliated Hospital of Yangzhou University
🇨🇳Yangzhou, Jiangsu, China
The fourth peoples hospital of zhenjiang city
🇨🇳Zhenjiang, Jiangsu, China
Affiliated Hospital of Jiujiang College
🇨🇳Jiujiang, Jiangxi, China
The First People's Hospital of Jingdehzne City
🇨🇳Jingdezhen, Jiangxi, China
Jiujiang first people's Hospital
🇨🇳Jiujiang, Jiangxi, China
First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Sino-Japanese Friendship Hospital Of Jilin University
🇨🇳Changchun, Jilin, China
The First Hospital Of Jilin University
🇨🇳Changchun, Jilin, China
Second People's Hospital of Huludao City
🇨🇳Huludao, Liaoning, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Guyuan people's hospital
🇨🇳Guyuan, Ningxia Hui Autonomous Region, China
First People's Hospital of Shenyang
🇨🇳Shenyang, Liaoning, China
The Fifth People's Hospital of Ningxia Hui Autonomous Region
🇨🇳Shizuishan, Ningxia Hui Autonomous Region, China
The Second People's Hospital of Shizuishan
🇨🇳Shizuishan, Ningxia Hui Autonomous Region, China
Shizuishan First People's Hospital
🇨🇳Shizuishan, Ningxia Hui Autonomous Region, China
Second people's Hospital of shizuishan
🇨🇳Shizuishan, Ningxia Hui Autonomous Region, China
Yinchuan First People's Hospital
🇨🇳Yinchuan, Ningxia Hui Autonomous Region, China
Xi 'an Fengcheng Hospital
🇨🇳Xi'an, Shaanxi, China
Putuo District Central Hospital
🇨🇳Shanghai, Shanghai, China
Hangzhou first people's Hospital
🇨🇳Hangzhou, Zhejiang, China
Liaocheng City Third People's Hospital
🇨🇳Liaocheng, Shandong, China
Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
The Brain Hospital of Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
Guanxian People's Hospital
🇨🇳LiaoCheng, Shandong, China
Datong Fifth People's Hospital
🇨🇳Datong, Shanxi, China
Shanxi cardiovascular disease hospital
🇨🇳Taiyuan, Shanxi, China
Fuzhou Second Hospital
🇨🇳Fuzhou, Fujian, China
Xiushan Tujia and Miao Autonomous County People's Hospital
🇨🇳Chongqing, Chongqing, China
The Second Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Zhangye People's Hospital Affiliated to Hexi College
🇨🇳Zhangye, Gansu, China
Hejian People's Hospital
🇨🇳Hejian, Hebei, China
The first Affiliated Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
Affiliated Hospital of Guizhou Medical University
🇨🇳Guiyang, Guizhou, China
The Second Hospitalof Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
The First Affiliated Hospital of Hebei North University
🇨🇳Zhangjiakou, Hebei, China
The First Affiliated Hospital of Jinan University
🇨🇳Guangzhou, Guangdong, China
Affiliated Hospital of Hebei Medical University
🇨🇳Baoding, Hebei, China
The Affiliated Hospital of Chengde Medical College
🇨🇳Chengde, Hebei, China
Changge People's Hospital
🇨🇳Changge, Henan, China
Jiyuan People's Hospital
🇨🇳Jiyuan, Henan, China
Kaifeng Central Hospital
🇨🇳Kaifeng, Henan, China
weishi county Central Hospital
🇨🇳Kaifeng, Henan, China
Wuhan No.1 Hospital
🇨🇳Wuhan, Hubei, China
Luoyang New District People's Hospital
🇨🇳Luoyang, Henan, China
Pingdingshan First People's Hospital
🇨🇳Pingdingshan, Henan, China
Shangqiu Fourth People's Hospital
🇨🇳Shangqiu, Henan, China
shaoyang Central Hospital
🇨🇳Shaoyang, Hunan, China
Inner Mongolia People's Hospital
🇨🇳Hohhot, Inner Mongolia Autonomous Region, China
Rugao People's Hospital
🇨🇳Nantong, Jiangsu, China
Nanjing Gaochun People's Hospital
🇨🇳Nanjing, Jiangsu, China
The Fourth Affiliated Hospital of Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China
Nanjing Jiangbei People's Hospital
🇨🇳Nanjing, Jiangsu, China
Nantong 6th People's Hospital
🇨🇳Nantong, Jiangsu, China
Rudong County People's Hospital
🇨🇳Nantong, Jiangsu, China
Tongzhou District 8th People's Hospital of Nantong City
🇨🇳Nantong, Jiangsu, China
Suqian People's Hospital
🇨🇳Suqian, Jiangsu, China
Jiangxi Provincial People's Hospital
🇨🇳Nanchang, Jiangxi, China
Jilin Provincial People's Hospital
🇨🇳Changchun, Jilin, China
Ningjin County People's Hospital
🇨🇳Dezhou, Shandong, China
Zhongwei People's Hospital
🇨🇳Zhongwei, Ningxia Hui Autonomous Region, China
Baoji High-tech People's Hospital
🇨🇳Baoji, Shaanxi, China
Shandong Provincial Hospital
🇨🇳Jinan, Shandong, China
Liaocheng Central Hospital
🇨🇳Liaocheng, Shandong, China
Linqing People's Hospital
🇨🇳Linqing, Shandong, China
Qingdao Municipal Hospital
🇨🇳Qingdao, Shandong, China
Yantai Beihai Hospita
🇨🇳Yantai, Shandong, China
Shanxi Bethune Hospital
🇨🇳Taiyuan, Shanxi, China
dazhou Central Hospital
🇨🇳Dazhou, Sichuan, China
Taiyuan Iron and Steel (Group) Co, Ltd,General Hospital
🇨🇳Taiyuan, Shanxi, China
Shenzhen Luohu People's Hospital
🇨🇳Shenzhen, Shenzhen, China
First People's Hospital of Yunnan Province
🇨🇳Kunming, Yunnan, China
People's Hospital Of Xinjiang Uygur Autonomous Region
🇨🇳Urumqi, Xinjiang Autonomous Region, China
Shanghai 7th People's Hospital
🇨🇳Shanghai, Shanghai, China
Anqing Municipal Hospital
🇨🇳Anqing, Anhui, China
The First Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, Anhui, China
Beijing Tian tan Hospital
🇨🇳Beijing, Beijing, China
Chongqing Fifth People's Hospital
🇨🇳Chongqing, Chongqing, China
Beijing Chaoyang Hospital, Capital MedicalUniversity（west Hospital）
🇨🇳Beijing, Beijing, China
The First Hospital of Fangshan District
🇨🇳Beijing, Beijing, China
Beijing Coal Group Hospital
🇨🇳Beijing, Beijing, China
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
Beijing Shunyi Airport Hospital
🇨🇳Beijing, Beijing, China
The Second Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Chongqing Sanbo Chang 'an Hospital
🇨🇳Chongqing, Chongqing, China
Daping Hospital of Army Military Medical University
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Chongqing People's Hospital
🇨🇳Chongqing, Chongqing, China
People's Hospital of Rongchang District, Chongqing,
🇨🇳Chongqing, Chongqing, China
The Third Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Chongqing Kaizhou District People's Hospital
🇨🇳Chongqing, Chongqing, China
Chongqing Fuling Central Hospital
🇨🇳Chongqing, Chongqing, China
Chongqing Three Gorges Central Hospital
🇨🇳Chongqing, Chongqing, China
Chongqing Nanchuan District People's Hospital
🇨🇳Chongqing, Chongqing, China
Nanfang Hospital Of Southern Medical University
🇨🇳Guangzhou, Guangdong, China
The First Hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Luoyang Central Hospital
🇨🇳Luoyang, Henan, China
Hongqi Hospital affiliated to Mudanjiang Medical University
🇨🇳Mudanjiang, Heilongjiang, China
Chenzhou First People's Hospital
🇨🇳Chenzhou, Hunan, China
The Central Hospital of Wuhan
🇨🇳Wuhan, Hubei, China
The First Affiliated Hospital of Nanhua University
🇨🇳Hengyang, Hunan, China
Loudi City Central Hospital
🇨🇳Loudi, Hunan, China
The first Affiliated Hospital of Baotou Medical College
🇨🇳Baotou, Inner Mongolia Autonomous Region, China
Xiangtan Central Hospital
🇨🇳Xiangtan, Hunan, China
Baotou CentralHospital
🇨🇳Baotou, Inner Mongolia Autonomous Region, China
Hulun Buir People's Hospital
🇨🇳Buri, Inner Mongolia Autonomous Region, China
Wuyuan County People's Hospital
🇨🇳Bayan Nur, Inner Mongolia Autonomous Region, China
Chifeng City Hospital
🇨🇳Chifeng, Inner Mongolia Autonomous Region, China
The second Affiliated Hospital of Baotou Medical College
🇨🇳Baotou, Inner Mongolia Autonomous Region, China
Affiliated Hospital of Chifeng University
🇨🇳Chifeng, Inner Mongolia Autonomous Region, China
Inner Mongolia International Mongolian Hospital
🇨🇳Hohhot, Inner Mongolia Autonomous Region, China
The Second People's Hospital of Lianyungang
🇨🇳Lianyungang, Jiangsu, China
Lianshui County People's Hospital
🇨🇳Huai'an, Jiangsu, China
Nanjing Jiangning Hospital
🇨🇳Nanjing, Jiangsu, China
Huaian Hospital of Traditional Chinese Medicine
🇨🇳Huai'an, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China
Nanjing Gulou Hospital
🇨🇳Nanjing, Jiangsu, China
BenQ Hospital affiliated to Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China
Nanjing Brain Hospital
🇨🇳Nanjing, Jiangsu, China
Nantong Hospital of Traditional Chinese Medicine
🇨🇳Nantong, Jiangsu, China
Nantong First People's Hospital
🇨🇳Nantong, Jiangsu, China
Nantong Fourth People's Hospital
🇨🇳Nantong, Jiangsu, China
Affiliated Hospital of Nantong University
🇨🇳Nantong, Jiangsu, China
The Third People's Hospital in Tongzhou District, Nantong
🇨🇳Nantong, Jiangsu, China
Nantong Second People's Hospital
🇨🇳Nantong, Jiangsu, China
Nantong Third People's Hospital
🇨🇳Nantong, Jiangsu, China
Tongzhou District People's Hospital of Nantong City
🇨🇳Nantong, Jiangsu, China
Siyang County People's Hospital
🇨🇳Suqian, Jiangsu, China
Suzhou Municipal Hospital
🇨🇳Suzhou, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Taizhou People's Hospital
🇨🇳Taizhou, Jiangsu, China
Jiangyin People's Hospital
🇨🇳Wuxi, Jiangsu, China
Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 1）
🇨🇳Xuzhou, Jiangsu, China
Yixing People's Hospital
🇨🇳Wuxi, Jiangsu, China
Ganzhou city people's Hospital
🇨🇳Ganzhou, Jiangxi, China
Xinhua Hospital affiliated to Dalian University
🇨🇳Dalian, Liaoning, China
Xian 141 Hospital
🇨🇳Xi'an, Shaanxi, China
People's Hospital of Ningxia Hui Autonomous Region
🇨🇳Yinchuan, Ningxia Hui Autonomous Region, China
weinan Central Hospital
🇨🇳Weinan, Shaanxi, China
Cardiovascular and Cerebrovoscular Hospital of General Hospital of Ningxia Med. Univ
🇨🇳Yinchuan, Ningxia Hui Autonomous Region, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia Hui Autonomous Region, China
Dezhou People's Hospital
🇨🇳Dezhou, Shandong, China
Xi 'an Hi-tech Hospital
🇨🇳Xi'an, Shaanxi, China
Liaocheng City Second People's Hospital
🇨🇳Liaocheng, Shandong, China
Liaocheng Veterans Hospital
🇨🇳Liaocheng, Shandong, China
Dongchangfu people's Hospital
🇨🇳Liaocheng, Shandong, China
Affiliated Hospital of Qingdao University Medical College
🇨🇳Qingdao, Shandong, China
Wendeng District People's Hospital
🇨🇳Weihai, Shandong, China
Affiliated Hospital of Weifang Medical University
🇨🇳Weifang, Shandong, China
Changzhi People's Hospital
🇨🇳Changzhi, Shanxi, China
Qingdao West Coast New Area People's Hospital
🇨🇳Qingdao, Shandong, China
Sunshine Union Hospital
🇨🇳Weifang, Shandong, China
Penglai People's Hospital
🇨🇳Yantai, Shandong, China
weihai Central Hospital
🇨🇳Weihai, Shandong, China
The First Hospital of Shanxi Medical University
🇨🇳Taiyuan, Shanxi, China
Heping Hospital affiliated to Changzhi Medical College
🇨🇳Changzhi, Shanxi, China
The Third People's Hospital of Datong
🇨🇳Datong, Shanxi, China
West China Hospital Of Sichuan University
🇨🇳Chengdou, Sichuan, China
Huazhong University of Science and Technology Union Shenzhen Hospital
🇨🇳Shenzhen, Shenzhen, China
Xi 'an First Hospital
🇨🇳Xi'an, Shanxi, China
Shenzhen Integrated Chinese and Western Medicine Hospital
🇨🇳Shenzhen, Shenzhen, China
Sichuan Provincial People's Hospital
🇨🇳Chengdu, Sichuan, China
Shenzhen Second People's Hospital
🇨🇳Shenzhen, Shenzhen, China
First Affiliated Hospital of Xinjiang Medical University
🇨🇳Guiyang, Xinjiang Autonomous Region, China
Chengdu second Municipal People'sHospital
🇨🇳Chengdu, Sichuan, China
lishui municipal Central Hospital
🇨🇳Lishui, Zhejiang, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
Friendship Hospital of Ili Kazak Autonomous Prefecture
🇨🇳Yining, Xinjiang Autonomous Region, China
Taizhou First People's Hospital
🇨🇳Taizhou, Zhejiang, China
Zhejiang Wenzhou Medical College Third Affiliated Hospital
🇨🇳Ruian, Zhejiang, China