Air Pollution and COPD Exacerbation

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Pollution; Exposure

• Registration Number: NCT03904875
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

There is an excess of hospitalization rates for acute exacerbation of COPD in Picardy compared to the national data. A first study realized in Picardy has shown a link between air quality and COPD. Nevertheless, the particles type is unknown and according to it, impact on COPD could be different. The investigator goal is to find a correlation between acute exacerbation of COPD consultation rate and daily ultra thin particles in Haut de France. The investigators will correlate the particles composition with daily acute exacerbation of COPD rate. All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie and Lille, and Clinique de l'Europe between 01/01/2020 and 31/12/2020 will be included. For each patient, home and work address will be collected. The duration of 1 year was chosen to take into account seasonal variations. In parallel, a daily report of the rate of ozone, particles (PM2.5 and PM10), dioxide nitrogen but also odours and pollens will be done by ATMO Haut de France.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-04-04
• Study First Submitted QC: 2019-04-04
• Study First Posted: 2019-04-05
• Study Start: 2020-01-01
• Primary Completion: 2022-03-12
• Status Verified: 2023-09
• Study Completion: 2023-09-12
• Last Update Submitted: 2023-09-12
• Last Update Posted: 2023-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• COPD patients with a diagnosis of acute exacerbation of COPD in the emergency room of Amiens and Lille centers
• Adults
• Patients able to express consent
• signed written informed consent form
• covered by national health insurance

Exclusion Criteria

• patients non covered by national health insurance
• patients not able to express consent
• minors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ultrathin particles quantity in the air	every day during 12 months	ultrathin particles quantity will be determined by the air of "Haut de France" by the company ATMO Haut de France.
daily rate of COPD exacerbation consultation in the emergency room of the 3 centers	every day during 12 months	daily rate of COPD exacerbation consultation in the emergency room of the 3 centers

Secondary Outcome Measures

Name	Time	Method
chemical composition ultrathin particles	every day during 12 months	chemical composition ultrathin particles will be determined by the air of "Haut de France" by the company ATMO Haut de France.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France