Endothelial microparticles as a diagnostic tool for the detection of subclinical myocardial ischemia.

Not Applicable

• Conditions: I25.13

• Registration Number: DRKS00000737
• Lead Sponsor: Medizinische Klinik und Poliklinik IIUniversitätsklinikum BonnRheinische Friedrich-Wilhelms-Universität

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Age =18 years, patients with proven coronary artery disease (CAD) or suspected CAD undergoing stress echocardiography before coronary angiography, written informed consent.

Exclusion Criteria

Age <18 years, acute coronary syndrome (STEMI, NSTEMI, unstable angina), severe heart valve defects, previous coronary artery bypass grafting, ineligibility for adequate echocardiography, contraindications for stress test (severe aortic stenosis, unstable angina, malignant arrhythmia, severe HOCM), pregnancy, mental disorders, decompensated heart failure (NYHA III and IV), allergy against contrast dye, hyperthyroidism.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase of microparticle level 4-6 and 18-24 hours after stress echocardiography determined by FACS (fluorescence-activated cell sorting) and association with myocardial ischemia.

Secondary Outcome Measures

Name	Time	Method
Comparison of different microparticle subtypes (endothelial versus thrombocyte origin) for the prediction of ischemia. <br>Relevance of microparticle level for the prediction of future major adverse cardiovascular and cerebral events (MACCE: cardiovascular death, myocardial infarction, stroke, target lesion revascularization)