Effects of sleeve gastrectomy on bone microarchitecture in patients with morbid obesity: a prospective cohort study using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT)
- Conditions
- morbid obesity
- Registration Number
- JPRN-UMIN000045812
- Lead Sponsor
- agasaki university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Not provided
1)Patients who receive treatment now, or have received treatment within the past 12 months, by bisphosphonates, PTH, anti-RANKL antibodies, or anti-sclerostin antibodies for osteoporosis. 2)Patients with thyroid disease requiring therapeutic intervention, parathyroid disease, primary aldosteronism, Cushing's syndrome, celiac disease, inflammatory bowel disease, renal dysfunction (estimated glomerular filtration rate < 30 ml/min), or hepatic dysfunction (AST > 3 times the upper limit of the reference value). 3)Patients who receive treatment by steroid. 4)Patients who have malignancy. 5)Patients who are pregnant or who may be pregnant. Patients who are lactating. 6)Patients who have participated in other clinical studies within 6 months. 7)Other patients who are judged by the investigators to be inappropriate as research subjects.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in bone microarchitecture at 6,12,24,and 36 months after start of treatment.
- Secondary Outcome Measures
Name Time Method Changes in bone mineral density and bone metabolism markers at 6,12,24,and 36 months after start of treatment.