Randomised controlled clinical trial to assess add on effect of Gudshuntyadi Yog in Tamaka Shwasa with special reference to Total Leucocyte Count and Differential Leucocyte Count

PRIMARY OBJECTIVE

To study add on effect of Gudshuntyadi yog in Tamaka shwasa withspecial reference to total leukocyte count and differential leucocyte count.

SECONDARY OBJECTIVES

1. To study Tamaka shwasa according to ayurvedic literature.

2. To study Bronchial asthma according to modern science.

3. To study, respiratory rate, peak expiratory flow rate,total leukocyte count

and differential leucocyte count.

4. To study relief in Tamaka shwasa by using Gudshuntyadi yog and changes in, respiratory rate, peakexpiratory flow rate,total leukocyte count and

differential leucocyte count in Tamaka shwasa by using Gudshuntyadi yog.

TYPE OF STUDY DESIGN: Open randomized controlled clinical study will be done.

Study setting:

OPD of Kayachikitsa and Panchkarma in our college.

Study population:

Random selection of patient by even odd method having Tamaka shwasa will be selected,data will be collected according to objective of the study in the case paper.Prevalence rate of Tamaka shwasa is 2.5%

Duration of Treatment:

30days.

METHODOLOGY:

The proposed study will be done in follow levels.

Drugs and diseases Review:

The drug and disease review will be taken from Ayurvedic classical texts

and from modern literature, research paper, research article, medical journals and related website.

Clinical Trials:

Assessment, screening, selection, randomization and follow-up

patients with intervention and investigation and documentation.

SUBJECTIVE CRITERIA:

1. Ghurghurtvum 2) Kasa 3) Dukhen kapha nissaran

2. Uraha peeda 5) Nidranash

OBJECTIVE CRITERIA:

1. Respiratory rate.

2. Peak expiratory flow rate value.

3. Total leucocyte count

4. Differential leucocyte count.

METHODS OF DATA COLLECTION:

The criteria of assessment will be based on subjective and

objective parameter.

Data analysis, plan & method:

1. Observations and results will be done with various graphs, diagrams,

chart and tables of observations.

2. Statistical analysis will be based on Paired t statistical test for objective parameter and Wilcoxon signed rank test for subjective parameter.

Collection and preparation of drug:

Drug will be procruited by GMP approved pharmacy

Equal quantity of Guda and Shunthi will be taken from GMP Approved pharmacy

Discussion :

Obtained data will be discussed

Conclusion:

It will be done strictly on the result obtained during the study.

Summary :

On the basis of observations, discussion and results summary will be drawn and whole dissertation work will be summarized.