Comparative evaluation of Injectable Platelet Rich Fibrin, Autologous Fibrin Glue and Hyaluronic Acid Gel for papilla reconstruction; A randomised clinical trial
Overview
- Phase
- Phase 3 4
- Status
- Not yet recruiting
- Sponsor
- Anjali Devi Patel
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically.
Overview
Brief Summary
This thesis presents a randomized clinical trial evaluating the effectiveness of injectable platelet-rich fibrin (i-PRF), autologous fibrin glue (AFG), and hyaluronic acid gel in reconstructing interdental papilla—the gum tissue between teeth. The study aims to compare these three biomaterials in terms of tissue regeneration, healing time, aesthetic outcomes, and patient comfort. Subjects with papilla loss received one of the treatments, and their progress was tracked over time. Results suggest that while all three approaches contributed to papilla reconstruction, i-PRF and AFG offered faster healing, and HA gel provided a minimally invasive option with promising cosmetic results.
Study Design
- Study Type
- Interventional
- Allocation
- Coin toss, Lottery, toss of dice, shuffling cards etc
- Masking
- Participant and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 55.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Patients aged between 18 to 55 years 2.Presence of interdental papillary loss in the maxillary anterior region 3.Good general health with no systemic conditions affecting periodontal healing 4.Willingness to participate and provide written informed consent 5.Presence of plaque index and gingival index scores within acceptable range.
Exclusion Criteria
- •Open contacts between the affected teeth.
- •Missing anterior teeth.
- •Pregnant or breastfeeding females
- •Patients with systemic diseases.
- •Patients with poor oral hygiene
- •Patients who take any medications known to cause gingival enlargement, gingival fillers previously done, teeth with caries, proximal restorations, fixed or orthodontic appliances.
- •Patients who had a periodontal surgeries six months prior to selection.
- •Severe periodontal bone loss.
Outcomes
Primary Outcomes
To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically.
Time Frame: To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically at the base line ,1 week, 1 month,3 month, 6.month
Secondary Outcomes
- • To evaluate the effectiveness and clinical outcome of the injectable -platelet rich fibrin injection in treatment of maxillary and mandibular interdental papillary deficiency.(• To evaluate the effectiveness and clinical outcome of the autologous fibrin glue injection in treatment of maxillary and mandibular interdental papillary deficiency.)
Investigators
Anjali Devi Patel
Faculty of Dental Sciences,IMS,BHU,Varanasi