High-Definition Transcranial Direct Current Stimulation on Episodic Memory in Individuals With Amnestic Mild Cognitive Impairment and History of TBI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Amnestic Mild Cognitive Impairment
- Sponsor
- University of Texas Southwestern Medical Center
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Hopkins Verbal Learning Test-Revised Total Learning
- Status
- Completed
- Last Updated
- 3 months ago
Overview
Brief Summary
The study will examine the efficacy of high definition transcranial direct current stimulation (HD-tDCS) and its influence on episodic memory in patients with amnestic mild cognitive impairment and a history of Traumatic brain injury. Ten sessions of HD-tDCS to the dorsal anterior cingulate region is expected to result in improvements in episodic memory measures immediately following the last session and at a 3-month follow-up.
Investigators
Christian Lobue
Associate Professor
University of Texas Southwestern Medical Center
Eligibility Criteria
Inclusion Criteria
- •Age 50 and older
- •Native English speakers
- •12 years of education or higher
- •Active diagnosis of aMCI
- •History of TBI based on VA/DOD criteria
Exclusion Criteria
- •TBI within the past 2 years
- •Lifetime history of stroke, transient ischemic attack, heart attack, or congestive heart failure
- •Lifetime history of epilepsy
- •Major psychiatric disorders (i.e., posttraumatic stress disorder, bipolar disorder, schizophrenia)
- •Substance use disorder
- •Has metal fragments in head
- •Taking medications that may interact with the HD-tDCS effect (i.e., amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, dextromethorphan, D-cycloserine, flunarizine, or ropinirole)
Outcomes
Primary Outcomes
Hopkins Verbal Learning Test-Revised Total Learning
Time Frame: Baseline, immediately following last HD-tDCS session, and again at 3-month follow-up
Episodic verbal memory will be assessed with the Hopkins Verbal Learning Test-Revised (HVLT-R). The HVLT-R is a verbal episodic memory task where a list of 12 words is read aloud for 3 consecutive trials followed by a 20 minute delayed recall trial. The number of items recalled immediately after each trial are summed to create a total learning score, ranging from 0-36. Also, the number of items recalled for the delayed trial are recorded as a delayed recall score, ranging from 0-12. Scores were converted to standardized scores (T-scores) using normative data, ranging from 2-86. Higher scores reflect better episodic memory performance.
Hopkins Verbal Learning Test-Revised Delayed Recall
Time Frame: Baseline, immediately following the last HD-tDCS session, and a 3-month follow-up
Episodic verbal memory will be assessed with the Hopkins Verbal Learning Test-Revised (HVLT-R). The HVLT-R is a verbal episodic memory task where a list of 12 words is read aloud for 3 consecutive trials followed by a 20 minute delayed recall trial. The number of items recalled immediately after each trial are summed to create a total learning score, ranging from 0-36. Also, the number of items recalled for the delayed trial are recorded as a delayed recall score, ranging from 0-12. Scores were converted to standardized scores (T-scores) using normative data, ranging from 2-86. Higher scores reflect better episodic memory performance.
Brief Visuospatial Memory Test-Revised (BVMT-R) Total Learning
Time Frame: Baseline, immediately post-treatment, and a 3 -month follow-up
Episodic verbal memory will be assessed with the Brief Visuospatial Memory Test-Revised (BVMT-R). The BVMT-R is a visual episodic memory task where where an array of 6 simple geometric visual designs are presented in a 2 x 3 matrix for 10 seconds for 3 trials. The number of items recalled immediately after each trial are summed for accuracy and placement to create a total learning score, ranging from 0-36. Also, the number of items recalled for the delayed trial are recorded as a delayed recall score, ranging from 0-12. Scores were converted to standardized scores (T-scores) using normative data, ranging from 2-86. Higher scores reflect better episodic memory performance.
Brief Visuospatial Memory Test-Revised Delayed Recall
Time Frame: Baseline, immediately post-treatment, and a 3-month follow-up
Episodic verbal memory will be assessed with the Brief Visuospatial Memory Test-Revised (BVMT-R). The BVMT-R is a visual episodic memory task where where an array of 6 simple geometric visual designs are presented in a 2 x 3 matrix for 10 seconds for 3 trials. The number of items recalled immediately after each trial are summed for accuracy and placement to create a total learning score, ranging from 0-36. Also, the number of items recalled for the delayed trial are recorded as a delayed recall score, ranging from 0-12. Scores were converted to standardized scores (T-scores) using normative data, ranging from 2-86. Higher scores reflect better episodic memory performance.
Secondary Outcomes
- Phonemic Fluency(Baseline, immediately post-treatment, and a 3-month follow-up)
- Semantic Fluency(Baseline, immediate post-treatment, and a 3-month follow-up)
- Trail Making Test(Baseline, immediate post-treatment, and a 3-month follow-up)
- Stroop Color and Word Test(Baseline, immediate post-treatment, and a 3-month follow-up)
- Digit Span Test(Baseline, immediate post-treatment, and a 3-month follow-up)