Fractalkine and CX3CR1 Dynamics in Gingivitis and Periodontitis Before and After Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Changes in the levels of biochemical parameters
研究概览
简要总结
This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.
详细描述
Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 47 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •25-50 years of age
- •having at least 20 natural teeth, excluding third molars
- •having no systemic disease
- •non-smokers
- •criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
- •criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.
排除标准
- •having any systemic diseases,
- •current pregnancy or lactation
- •a history of periodontal treatment in the past 6 months
- •using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.
结局指标
主要结局
Changes in the levels of biochemical parameters
时间窗: Baseline and 1 and 3 months after treatment
The levels of Fractalkine and CX3CR1 before and after periodontal treatment in gingivitis and periodontitis patients.
次要结局
未报告次要终点
研究者
Zeynep Pınar Yucel
Assoc. Prof.
Giresun University