Attention Modulation of Local and Global Inhibition Mechanisms

Not Applicable

Recruiting

• Conditions: Optical Phenomena
• Interventions: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades"

• Registration Number: NCT04279158
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. These mechanisms are not independent of attentional control. Attention acts as a selection filter for the investigator's behavior. This leads us to hypothesize that attention modulates the mechanisms of inhibition. Nevertheless, the different brain structures involved, as well as mechanisms underlying the interaction between inhibition and attention remain largely unknown.

Previous research has suggested that inhibition requires selective attention and, conversely, attentional mechanisms would result in the "deselection", or inhibition, of objects in space or irrelevant actions. Reconciling the literature on attention with the one on inhibition appears fundamental for the understanding of the instance to which the mechanisms of inhibition and the cognitive processes interact. Therefore, the goal of this research project will be to investigate how inhibition mechanisms are implemented in the brain and, in more detail, what determines the type of resulting inhibitory control: spatially localized or global. The investigator will test 3 different patient groups (optic ataxia, hemispatial neglect and attention-deficit hyperactivity disorder) compared to control.

In conclusion, this research project will aim to develop a theoretical model of the interaction between attentional control and inhibition mechanisms in order to improve diagnostic and rehabilitation tools in the future.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-02-11
• Study First Submitted QC: 2020-02-19
• Study First Posted: 2020-02-21
• Study Start: 2022-11-26
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-29
• Last Update Posted: 2024-01-30
• Primary Completion: 2028-11-26
• Study Completion: 2028-11-26

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• male and female, age from 18 to 75 years included
• normal vision or corrected vision
• covered by social security
• signed written informed consent

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Exclusion Criteria

• unable to comply with requirements of the study (neurological, psychiatric, sensory or motor troubles)
• adults under legal protection

Patient with hemispatial neglect:

Inclusion Criteria:

• After a stroke (> 1 month ago), presence of a neurological impairment documented by brain imaging (standard of care) and by clinical symptoms.
• The diagnosis will be dissociated from hemianopia by perimetry. The hemispatial neglect consists of a lack of perception and responsiveness concerning the controlesional visual hemifield.

Patient with optic ataxia:

• After a stroke (> 1 month ago), presence of neurological injury in parietal cortex only, supported by a standard of care cerebral MRI
• Present optic ataxia symptoms (The OA consists of pointing errors with the hand contralateral to the lesion (hand effect) and / or to visual targets presented in the field contralateral to the lesion (field effect)).

Patient (adult and children) with attention-deficit hyperactivity disorder:

• present a diagnosis of ADHD subtype inattention or impulse / hyperactivity as established by a neuropsychologist.
• Children will be between 8 and 18 years old
• Adults will be between 18 and 75 years old.
• Participants will not report any comorbid learning disabilities to ADHD.

For minors:

• Having obtained the written consent of the legal representative(s)

Healthy subjects

Inclusion Criteria:

• no known neurological injury

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patients with optic ataxia (OA)	experience 3 "Anti-saccades"	-
patients with optic ataxia (OA)	experience 2 "Stop signal task"	-
patients with hemispatial neglect	experience 2 "Stop signal task"	-
patients with attention-deficit hyperactivity disorder	experience 3 "Anti-saccades"	-
patients with hemispatial neglect	experience 1 "The negative priming task"	-
patients with optic ataxia (OA)	experience 1 "The negative priming task"	-
patients with attention-deficit hyperactivity disorder	experience 1 "The negative priming task"	-
Healthy volunteers	experience 2 "Stop signal task"	-
Healthy volunteers	experience 3 "Anti-saccades"	-
patients with attention-deficit hyperactivity disorder	experience 2 "Stop signal task"	-
patients with hemispatial neglect	experience 3 "Anti-saccades"	-
Healthy volunteers	experience 1 "The negative priming task"	-

Primary Outcome Measures

Name	Time	Method
error rate	at the end of the simulation passage, an average of 3 years	The investigator calculate the number of right and wrong answers (a correct answer is a saccade carried out when it is necessary and by reaching the target; a false answer is a saccade made at the wrong time and / or not reaching the target) to obtain the error rate.

Secondary Outcome Measures

Name	Time	Method
reaction time	at the end of the simulation passage, an average of 3 years	The investigator measure the time it takes for the subject to respond (perform the eye saccade)

Trial Locations

Locations (1)

Centre de Recherche en Neuroscience de Lyon; 🇫🇷 Bron, France